| Feasibility of 11C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall. | |
| | |
MedLine Citation:
|
PMID: 22065877 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Fatty acids are a common constituent of atherosclerotic plaque and may be synthesized in the plaque itself. Fatty acid synthesis requires acetyl-coenzyme-A (CoA) as a main substrate, which is produced from acetate. Currently, (11)C-acetate PET/CT is used for the evaluation of malignancies. There are no data concerning its potential for the characterization of atherosclerotic plaque. Therefore, the purpose of the present study was to examine the prevalence, distribution, and topographic relationship of arterial (11)C-acetate uptake and vascular calcification in major arteries. METHODS: Thirty-six patients were examined by whole-body (11)C-acetate PET/CT. Tracer uptake in various arterial segments was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio). CT images were used to measure calcified plaque burden. RESULTS: (11)C-acetate uptake was observed at 220 sites in 32 (88.8%) of the 36 study patients, and mean target-to-background ratio was 2.5 ± 1.0. Calcified atherosclerotic lesions were observed at 483 sites in 30 (83.3%) patients. Sixty-four (29.1%) of the 220 lesions with marked (11)C-acetate uptake were colocalized with arterial calcification. However, only 13.3% of all arterial calcification sites demonstrated increased radiotracer accumulation. CONCLUSION: Our data indicate the feasibility of using (11)C-acetate PET/CT for imaging of fatty acid synthesis in the atherosclerotic vessel wall. This study provides a rationale to incorporating (11)C-acetate PET into further preclinical and clinical studies to obtain new insights into fatty acid synthesis in atherosclerotic lesions and to evaluate whether it may be used to monitor pharmacologic intervention with fatty acid synthase inhibitors. |
| | |
Authors:
|
Thorsten Derlin; Christian R Habermann; Zsolt Lengyel; Jasmin D Busch; Christian Wisotzki; Janos Mester; László Pávics |
Related Documents
:
|
1878107 - Marine biosurfactants, ii. production and characterization of an anionic trehalose tetr... 21899477 - Antithrombotic lipids from semen persicae. 903047 - The mechanism of adipocere formation. ii. separation and identification of oxo fatty ac... 83207 - Di-, mono- and nonphytanyl triglycerides in the serum: a sensitive parameter of the phy... 17294817 - Cardio-selective inhibitory effect of the betel nut extract: possible explanation. 8631127 - Induction of the transcription factor ap-1 in cultured human colon adenocarcinoma cells... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: - ISSN: 1535-5667 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg-Eppendorf, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In Vivo Near-Infrared Fluorescence Imaging of Integrin ?2?1 in Prostate Cancer with Cell-Penetrating...
Next Document: Avoiding complications with aptos sutures.