| Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates. | |
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MedLine Citation:
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PMID: 19587546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cellular state of quiescence is characterized by an exit from the cell cycle that is reversible, that is, upon appropriate stimulation, quiescent cells can re-enter the cell cycle, proliferate and produce progeny. In this way, quiescent cells can be distinguished from cells in an irreversibly arrested state such as senescence or terminal differentiation. The molecular basis for reversible versus irreversible cell cycle arrest is unclear. In a recent study, we demonstrated that the transcriptional regulator Hes1 has a role in maintaining fibroblasts in a reversible quiescent state: overexpression of Hes1 protects fibroblasts against senescence or differentiation, and inhibition of endogenous Hes1 makes quiescent fibroblasts more susceptible to these states. Here we describe the molecular mechanisms by which Hes1 regulates gene expression by modifying histone tails and thus affecting chromatin conformation. We put forward models for how Hes1 is regulated and how it protects quiescent cells from differentiation and senescence. |
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Authors:
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Liyun Sang; Hilary A Coller |
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Publication Detail:
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Type: Journal Article Date: 2009-07-26 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 8 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-10-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2161-7 Citation Subset: IM |
Affiliation:
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Genentech, 1 DNA way, South San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Basic Helix-Loop-Helix Transcription Factors / metabolism* Cell Aging Cell Differentiation Cell Line Fibroblasts / cytology*, metabolism G0 Phase Homeodomain Proteins / metabolism* Humans Receptors, Notch / metabolism Signal Transduction Sirtuin 1 Sirtuins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/Homeodomain Proteins; 0/Receptors, Notch; 149348-15-2/HES1 protein, human; EC 3.5.1.-/SIRT1 protein, human; EC 3.5.1.-/Sirtuin 1; EC 3.5.1.-/Sirtuins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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