| Fe(III)-salen and salphen complexes induce caspase activation and apoptosis in human cells. | |
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MedLine Citation:
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PMID: 21045212 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To explore the apoptotic and antitumor activities of metallo-salens, the authors have synthesized several Fe(III)-salen and salphen complexes and analyzed their effects on human cancer and noncancer cells. Their results demonstrated that Fe(III)-salen and salphen complexes affect cell viability and induce nuclear fragmentation and apoptosis in breast cancer (MCF7) cells. The IC(50) values for the active metallo-salen complexes ranged between 0.3 and 22 µM in MCF7 cells. Biochemically active Fe(III)-salen and salphen complexes induced caspase-3/7 activation and release of cytochrome c from the mitochondria to cytosol, suggesting the involvement of the mitochondrial pathway of apoptosis. Comparison of IC(50) values toward 3 different cell lines demonstrated that selected Fe(III)-salen complexes induce tumor cell-selective apoptosis in cultured cells. Overall, the studies demonstrated that Fe(III)-salen and salphen complexes induced efficient apoptosis in cultured human cells. The nature of the substituents and the bridging spacer between diamino groups play critical roles in determining the apoptotic activities of Fe(III)-salen and salphen complexes. |
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Authors:
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Khairul I Ansari; Sahba Kasiri; James D Grant; Subhrangsu S Mandal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-02 |
Journal Detail:
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Title: Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening Volume: 16 ISSN: 1552-454X ISO Abbreviation: J Biomol Screen Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612112 Medline TA: J Biomol Screen Country: United States |
Other Details:
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Languages: eng Pagination: 26-35 Citation Subset: IM |
Affiliation:
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Gene Regulation and Disease Research Laboratory, Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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