| Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 15878375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmaceutical grade magnetic colloidal dispersions have been prepared from iron alloys synthesized by laser pyrolysis. The colloids were obtained by simultaneous dispersion and coating of the particles with dextran in a strong alkaline solution. Both powders and dispersions have been analyzed in terms of microstructural characteristics, chemical composition and magnetic properties. The powders consist of uniform spherical nanoparticles (12 nm of diameter) showing a metallic core encapsulated into an iron-oxide shell. On the other hand, the colloidal dispersions consist of magnetic particles-aggregates with hydrodynamic sizes of approximately 75 nm. Magnetic resonance images of rats were taken after the intravenously administration of the Fe colloidal dispersions, and compared with those obtained using a commercial iron oxide magnetic resonance imaging contrast agent. The results showed a contrast improvement of 60% in the liver with respect to the commercial sample, which suggests that this product could be a suitable contrast agent for NMR imaging of liver and spleen. |
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Authors:
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Oscar Bomatí-Miguel; María P Morales; Pedro Tartaj; Jesús Ruiz-Cabello; Pierre Bonville; Martín Santos; Xinqing Zhao; Sabino Veintemillas-Verdaguer |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-04-18 |
Journal Detail:
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Title: Biomaterials Volume: 26 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-05-09 Completed Date: 2005-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 5695-703 Citation Subset: IM |
Affiliation:
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Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés del Cruz 3, Campus de Cantoblanco, Madrid, 28049, Spain. obomatim@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloys
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chemistry,
diagnostic use,
pharmacokinetics Animals Contrast Media / chemistry, pharmacokinetics* Image Enhancement / methods* Iron / chemistry, diagnostic use*, pharmacokinetics* Liver / anatomy & histology*, metabolism* Magnetic Resonance Imaging / methods* Male Metabolic Clearance Rate Nanotubes / chemistry, ultrastructure Organ Specificity Rats Rats, Wistar Spleen / anatomy & histology, metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Alloys; 0/Contrast Media; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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