Document Detail


The FcgammaRIIa-polymorphic site as a potential target for acute graft-versus-host disease in allogeneic stem cell transplantation.
MedLine Citation:
PMID:  15744239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Graft-versus-host disease (GVHD) is a serious complication of allogeneic stem cell transplantation for hematologic diseases. Antigen mismatches due to polymorphic differences between the patient and donor are central in the mechanisms of GVHD. Polymorphisms are known for FcgammaRIIa, and this molecule is present on endothelial, dendritic, and Langerhans cells. Donor cells reacting against the patient as GVHD can also react against the malignancy of the patient, and this is known as the graft-versus-leukemia (GVL) effect. Because the FcgammaRIIa molecule is also present on acute myeloid leukemia (AML) cells, an FcgammaRIIa mismatch could be a target for both GVHD and GVL. We retrospectively studied 73 AML patients and analyzed the differences in GVHD and relapse incidence between patients with and without a pro-GVHD/GVL FcgammaRIIa allotype mismatch. We observed a difference in FcgammaRIIa receptors with a pro-GVHD/GVL mismatch in 18 patient/donor pairs (25%). Univariate and multivariate analyses demonstrated the pro-GVHD mismatch to be a significant risk factor for the development of acute GVHD. There was no effect on the occurrence of chronic GVHD. The relapse incidence was not significantly different for patients with or without the pro-GVL mismatch, although there was a trend for fewer relapses in standard-risk AML patients with the pro-GVL mismatch. We conclude that the polymorphism of the FcgammaRIIa receptor may be a candidate target for acute GVHD.
Authors:
Hanneke M van der Straaten; Rob Fijnheer; H Karel Nieuwenhuis; Jan G J van de Winkel; Leo F Verdonck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     Volume:  11     ISSN:  1083-8791     ISO Abbreviation:  Biol. Blood Marrow Transplant.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-03     Completed Date:  2005-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600628     Medline TA:  Biol Blood Marrow Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  IM    
Affiliation:
Department of Haematology, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Analysis of Variance
Antigens, CD / genetics*
Cohort Studies
Female
Graft vs Host Disease / genetics*,  immunology
Graft vs Leukemia Effect / genetics,  immunology
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Incidence
Leukemia, Myeloid / complications,  therapy
Male
Middle Aged
Polymorphism, Genetic*
Receptors, IgG / genetics*
Recurrence
Retrospective Studies
Transplantation Immunology
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Fc gamma receptor IIA; 0/Receptors, IgG

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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