| The FcgammaRIIa-polymorphic site as a potential target for acute graft-versus-host disease in allogeneic stem cell transplantation. | |
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MedLine Citation:
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PMID: 15744239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Graft-versus-host disease (GVHD) is a serious complication of allogeneic stem cell transplantation for hematologic diseases. Antigen mismatches due to polymorphic differences between the patient and donor are central in the mechanisms of GVHD. Polymorphisms are known for FcgammaRIIa, and this molecule is present on endothelial, dendritic, and Langerhans cells. Donor cells reacting against the patient as GVHD can also react against the malignancy of the patient, and this is known as the graft-versus-leukemia (GVL) effect. Because the FcgammaRIIa molecule is also present on acute myeloid leukemia (AML) cells, an FcgammaRIIa mismatch could be a target for both GVHD and GVL. We retrospectively studied 73 AML patients and analyzed the differences in GVHD and relapse incidence between patients with and without a pro-GVHD/GVL FcgammaRIIa allotype mismatch. We observed a difference in FcgammaRIIa receptors with a pro-GVHD/GVL mismatch in 18 patient/donor pairs (25%). Univariate and multivariate analyses demonstrated the pro-GVHD mismatch to be a significant risk factor for the development of acute GVHD. There was no effect on the occurrence of chronic GVHD. The relapse incidence was not significantly different for patients with or without the pro-GVL mismatch, although there was a trend for fewer relapses in standard-risk AML patients with the pro-GVL mismatch. We conclude that the polymorphism of the FcgammaRIIa receptor may be a candidate target for acute GVHD. |
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Authors:
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Hanneke M van der Straaten; Rob Fijnheer; H Karel Nieuwenhuis; Jan G J van de Winkel; Leo F Verdonck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: 11 ISSN: 1083-8791 ISO Abbreviation: Biol. Blood Marrow Transplant. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-03 Completed Date: 2005-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 206-12 Citation Subset: IM |
Affiliation:
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Department of Haematology, University Medical Center Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Analysis of Variance Antigens, CD / genetics* Cohort Studies Female Graft vs Host Disease / genetics*, immunology Graft vs Leukemia Effect / genetics, immunology Hematopoietic Stem Cell Transplantation / adverse effects* Humans Incidence Leukemia, Myeloid / complications, therapy Male Middle Aged Polymorphism, Genetic* Receptors, IgG / genetics* Recurrence Retrospective Studies Transplantation Immunology Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Fc gamma receptor IIA; 0/Receptors, IgG |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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