| FcgammaRIIa genotype predicts progression of HIV infection. | |
| | |
MedLine Citation:
|
PMID: 18025239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Polymorphisms in FcgammaR genes are associated with susceptibility to or severity of a number of autoimmune and infectious diseases. We found that HIV-infected men in the Multicenter AIDS Cohort Study with the FcgammaRIIa RR genotype progressed to a CD4(+) cell count of <200/mm(3) at a faster rate than individuals with the RH or HH genotypes (relative hazard = 1.6; p = 0.0001). However, progression to AIDS (using the broad definition of either a CD4(+) cell count <200/mm(3) or development of an AIDS-defining illness) was less impacted by FcgammaRIIa genotype, largely because HH homozygotes had an increased risk of Pneumocystis jiroveci pneumonia as an AIDS-defining illness. We also showed that chronically infected subjects develop a substantial anti-gp120-specific IgG2 response. Moreover, HIV-1 immune complexes are more efficiently internalized by monocytes from HH subjects compared with RR subjects, likely because of the presence of IgG2 in the complexes. Finally, the FcgammaRIIIa F/V gene polymorphism was not associated with progression of HIV infection, but, as demonstrated previously, did predict the risk of Kaposi's sarcoma. These results demonstrate the importance of FcgammaRs in AIDS pathogenesis and point toward a critical role for interactions between FcgammaRs and immune complexes in disease progression. |
| | |
Authors:
|
Donald N Forthal; Gary Landucci; Jay Bream; Lisa P Jacobson; Tran B Phan; Benjamin Montoya |
Related Documents
:
|
1747059 - Aids, drugs of abuse and the immune system: a complex immunotoxicological network. 2505609 - A case of encephalitozoon cuniculi peritonitis in a patient with aids. 8958299 - Incarceration and the acquired immunodeficiency syndrome: autopsy results in texas pris... 8196559 - Mucosal origin of aids. 22305949 - Contextual influences on the development of obesity in children: a case study of uk sou... 8209399 - Signal transduction defect in the acquired immunodeficiency syndrome and aids-related c... 10397429 - Emotional and behavioural problems in adolescents/young adults receiving treatment at a... 20124919 - A computer-aided cobb angle measurement method and its reliability. 1082409 - A system-structured medical record for intensive care patient documentation. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 179 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-20 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 7916-23 Citation Subset: AIM; IM |
Affiliation:
|
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA. dnfortha@uci.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antigens, CD / genetics* CD4 Lymphocyte Count CD4-Positive T-Lymphocytes / immunology, virology Cohort Studies Disease Progression Genotype HIV / immunology HIV Infections / diagnosis*, genetics*, immunology Humans Male Middle Aged Predictive Value of Tests Receptors, IgG / genetics* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
5 M01 RR00722/RR/NCRR NIH HHS; U01 AI35039/AI/NIAID NIH HHS; U01 AI35040/AI/NIAID NIH HHS; U01 AI35041/AI/NIAID NIH HHS; U01 AI35042/AI/NIAID NIH HHS; U01 AI35043/AI/NIAID NIH HHS; U01 AI37613/AI/NIAID NIH HHS; U01 AI37984/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/Fc gamma receptor IIA; 0/Receptors, IgG |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendrit...
Next Document: Effective proliferation of human regulatory T cells requires a strong costimulatory CD28 signal that...