| Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis. | |
| | |
MedLine Citation:
|
PMID: 15367919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcgamma receptor II (FcgammaRII) is involved in host defense against microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF. We studied 167 Italian unrelated patients with CF and 50 control subjects. The distribution of FcgammaRIIA genotypes in CF patients was compared with that in control subjects and the different genotypes were related with the presence or absence of P. aeruginosa infection and markers of disease severity in CF patients. The distribution of FcgammaRIIA genotypes was not significantly different between CF patients and controls. We observed that in CF patients with the same CFTR genotype (DeltaF508/DeltaF508), those carrying the R allele of FcgammaRIIA had an increased risk of acquiring chronic P. aeruginosa infection (P=0.042, R.R.: 4.38; 95% CI: 1.17/22.4). Moreover, the frequency of R/R genotype in patients with chronic P. aeruginosa infection seems to be higher than that of control subjects and patients without chronic infection. The observation that CF patients carrying the R allele of FcgammaRIIA are at higher risk of acquiring chronic P. aeruginosa infection suggests that the FcgammaRII loci genetic variation is contributing to this infection susceptibility. |
| | |
Authors:
|
Virginia De Rose; Carlo Arduino; Nazario Cappello; Rita Piana; Paola Salmin; Marco Bardessono; Manuela Goia; Rita Padoan; Elisabetta Bignamini; Diana Costantini; Giovanna Pizzamiglio; Veronica Bennato; Carla Colombo; Annamaria Giunta; Alberto Piazza |
Related Documents
:
|
17276369 - Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. 7320509 - To the problem of secondary mycotic infections and their etiological agents. 18718399 - Identification of aspergillus species in oral tissue samples of patients with hematolog... 6368399 - Defective phagocyte aspergillus killing associated with recurrent pulmonary aspergillus... 2921549 - Mycotic infection of the ear (otomycosis): a prospective study. 2966159 - Fungal microabscesses in immuno-suppressed patients--ct appearances. 16532589 - Cytokines and clinical manifestations of malaria in adults with severe and uncomplicate... 18626429 - Hepatitis b virus and hepatocarcinogenesis. 11125889 - Immunolocalization of hiv envelope gp120 in hiv encephalitis with dementia. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of human genetics : EJHG Volume: 13 ISSN: 1018-4813 ISO Abbreviation: Eur. J. Hum. Genet. Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2004-12-16 Completed Date: 2005-04-26 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9302235 Medline TA: Eur J Hum Genet Country: England |
Other Details:
|
Languages: eng Pagination: 96-101 Citation Subset: IM |
Affiliation:
|
Respiratory Disease Division, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. virginia.derose@unito.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Alleles Case-Control Studies Child Cystic Fibrosis / genetics*, immunology, microbiology* Cystic Fibrosis Transmembrane Conductance Regulator / genetics Disease Susceptibility Female Genetic Variation Genotype* Humans Male Middle Aged Neutrophils / metabolism Pseudomonas Infections / genetics*, immunology Pseudomonas aeruginosa / genetics, immunology Receptors, IgG / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/CFTR protein, human; 0/FCGR2A protein, human; 0/FCGR2B protein, human; 0/Receptors, IgG; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity.
Next Document: A new form of autosomal dominant limb-girdle muscular dystrophy (LGMD1G) with progressive fingers an...