| A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection. | |
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MedLine Citation:
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PMID: 21849464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strategies to prevent the sexual transmission of HIV include vaccines that elicit durable, protective mucosal immune responses. A key to effective mucosal immunity is the capacity for antigens administered locally to cross epithelial barriers. Given the role of neonatal Fc receptor (FcRn) in transferring IgG across polarized epithelial cells which line mucosal surfaces, FcRn might be useful for delivering HIV vaccine antigens across mucosal epithelial barriers to the underlying antigen-presenting cells. Chimeric proteins composed of HIV Gag (p24) fused to the Fc region of IgG (Gag-Fc) bind efficiently to airway mucosa and are transported across this epithelial surface. Mice immunized intranasally with Gag-Fc plus CpG adjuvant developed local and systemic immunity, including durable B and T cell memory. Gag-specific immunity was sufficiently potent to protect against an intravaginal challenge with recombinant vaccinia virus expressing the HIV Gag protein. Intranasal administration of a Gag-Fc/CpG vaccine protected at a distal mucosal site. Our data suggest that targeting of FcRn with chimeric immunogens may be an important strategy for mucosal immunization and should be considered a new approach for preventive HIV vaccines. |
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Authors:
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Li Lu; Senthilkumar Palaniyandi; Rongyu Zeng; Yu Bai; Xindong Liu; Yunsheng Wang; C David Pauza; Derry C Roopenian; Xiaoping Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-17 |
Journal Detail:
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Title: Journal of virology Volume: 85 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-22 Completed Date: 2011-11-07 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 10542-53 Citation Subset: IM |
Affiliation:
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Laboratory of Immunology, University of Maryland, College Park, MD 20742, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Vaccines
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administration & dosage,
genetics,
immunology* Adjuvants, Immunologic / administration & dosage Administration, Intranasal Animals B-Lymphocytes / immunology Female HIV Core Protein p24 / genetics, immunology* HIV Infections / prevention & control Histocompatibility Antigens Class I / immunology* Immunoglobulin Fc Fragments / genetics, immunology* Immunologic Memory Mice Mice, Inbred C57BL Oligodeoxyribonucleotides / administration & dosage Receptors, Fc / immunology* Recombinant Fusion Proteins / genetics, immunology T-Lymphocytes / immunology Vaccines, Synthetic / genetics, immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI65892/AI/NIAID NIH HHS; AI67965/AI/NIAID NIH HHS; AI73139/AI/NIAID NIH HHS; DK56597/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/AIDS Vaccines; 0/Adjuvants, Immunologic; 0/CPG-oligonucleotide; 0/Fc receptor, neonatal; 0/HIV Core Protein p24; 0/Histocompatibility Antigens Class I; 0/Immunoglobulin Fc Fragments; 0/Oligodeoxyribonucleotides; 0/Receptors, Fc; 0/Recombinant Fusion Proteins; 0/Vaccines, Synthetic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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