Document Detail


Fc gamma R IIIB polymorphisms: their association with clinical manifestations and autoantibodies in SLE patients from western India.
MedLine Citation:
PMID:  20536598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Receptors for the Fc fragment of immunoglobulin G (Fc gamma Rs) represent the link between the humoral and cellular immune responses. Polymorphisms of Fc gamma R, mainly IIA, IIB, IIIA, IIIB have been identified as genetic factors influencing susceptibility to disease or disease course of a prototype autoimmune disease like systemic lupus erythematosus (SLE). Fc gamma alleles may be associated with inefficient removal of apoptotic cells or antigens and hence may be associated with higher risk of SLE. OBJECTIVE: This study was designed to look for Fc gamma R IIIB polymorphisms of three different alleles, NA1, NA2 and SH in SLE patients and to correlate the distribution of Fc gamma R IIIB genotypes with clinical presentation and autoantibody profile. MATERIAL AND METHODS: Eighty SLE patients along with eighty normal individuals were studied. Fc gamma R IIIB polymorphism was tested by allele-specific primer amplification. RESULTS: The percentage distribution of NA1/NA1, NA1/NA2 and NA2/NA2 was 22.5%, 40% and 37.5%, respectively, among the normal population; and among SLE patients it was 25%, 40% and 35%, respectively. The percentage distribution of SH allele was 68.8% among the normal population, while in SLE patients it was 60%. No statistical difference was found in the distribution of Fc gamma R IIIB genotypes in patients of lupus nephritis and SLE without nephritis (P > 0.05). CONCLUSION: Among SLE patients studied, NA2 was the prominent allele. It was commonly associated with clinical manifestations such as skin rash, arthritis, hematological and immunological disorders. This suggests that the primary involvement of Fc gamma R IIIB NA2 allele is more likely involved with disease susceptibility of SLE.
Authors:
Vandana Pradhan; Neha Deshpande; Anita Nadkarni; Manisha Patwardhan; Prathamesh Surve; Kanjaksha Ghosh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of rheumatic diseases     Volume:  13     ISSN:  1756-185X     ISO Abbreviation:  Int J Rheum Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474930     Medline TA:  Int J Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  138-43     Citation Subset:  IM    
Affiliation:
Department of Autoimmune Disorders, National Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital, Parel, Mumbai, Maharashtra, India. pradhanv69@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies
Cross-Sectional Studies
Female
Genetic Predisposition to Disease*
Genotype
Health Status
Humans
Isoantigens / genetics,  immunology
Lupus Erythematosus, Systemic / genetics*,  immunology*,  physiopathology
Male
Polymorphism, Genetic*
Receptors, IgG / genetics*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/FCGR3B protein, human; 0/Isoantigens; 0/Receptors, IgG; 0/neutrophil-specific antigen NA1, human; 0/neutrophil-specific antigen NA2; 0/neutrophil-specific antigen SH

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