Document Detail

Favourable interaction of calcium antagonist plus ACE inhibitor on cardiac haemodynamics in treating hypertension: rest and effort evaluation.
MedLine Citation:
PMID:  7783096     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate the effects of verapamil sustained release (SR) 240 mg, enalapril and their combination on blood pressure (BP) and cardiac haemodynamics at rest and during exercise in 20 patients with moderate essential hypertension (seven men and 13 women, mean age +/- s.d. 53.7 +/- 15.8 years). After a 4 week placebo run-in period, patients were randomly allocated to received verapamil SR 240 mg once daily or enalapril 20 mg once daily for 4 weeks in a double-blind fashion. Patients whose diastolic blood pressure (DBP) was still > or = 95 mm Hg at the end of this period received verapamil SR plus enalapril for an additional 4 weeks. At the end of the placebo, single and combined treatment periods, resting and exercise (bicycle ergometry) haemodynamics were evaluated by radionuclide ventricular angiography (technetium-99m) and the following parameters were assessed: BP, heart rate, double product, systemic vascular resistances (SVR), cardiac output (CO), stroke volume (SV), ejection fraction (EF) mean ejection rate (mER) and peak filling rate (PFR). Both verapamil SR and enalapril monotherapies significantly reduced resting and exercise BP (P < 0.01), with a BP normalisation (DBP < or = 95 mm Hg) of five of 10 and 4 of 10 patients respectively. A greater BP fall and a normalisation of 11 of 11 patients was obtained in non-responders to monotherapy, when treated with verapamil SR and enalapril (P < 0.01). Verapamil SR also reduced heart rate at rest and during exercise (-11.8% and -18.4%, respectively, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
S Di Somma; A Carotenuto; M de Divitiis; A Paulucci; M Galderisi; A Cuocolo; O de Divitiis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  9     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-17     Completed Date:  1995-07-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Cardioangiology Department, Medical School University Federico II, Naples, Italy.
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MeSH Terms
Blood Pressure / drug effects
Drug Combinations
Drug Interactions
Enalapril / administration & dosage,  therapeutic use*
Heart / drug effects,  physiopathology
Hemodynamics / drug effects
Hypertension / drug therapy*
Middle Aged
Verapamil / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 52-53-9/Verapamil; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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