Document Detail


Favorable pregnancy, delivery, and implantation rates experienced in embryo donation programs in the United States.
MedLine Citation:
PMID:  18001717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To document the numbers of donated frozen ETs performed and the pregnancy, birth, and embryo implantation rates seen in four infertility clinics and three embryo donation agencies in the United States. DESIGN AND SETTING: Case series. Four infertility clinics and three embryo donation agencies in the United States contributed data from their first year of available information through calendar year 2006. The programs reported numbers of donated frozen ETs, numbers of pregnancies delivered from these transfers, and numbers of these pregnancies lost to miscarriage or stillbirth. For each pregnancy, the programs reported the number of gestational sacs identified and the number of resulting live births. PATIENT(S): N/A. INTERVENTION(S): N/A. MAIN OUTCOME MEASURE(S): Pregnancy rate, delivery rate per ET, implantation rate, live birth rate per embryo transferred, and "implantation potential" (gestational sacs identified per embryo thawed). RESULT(S): These programs performed 702 ETs, resulting in 314 clinical pregnancies (44.7%) and 249 deliveries (35.5%). With 3,103 embryos thawed and 2,078 embryos transferred, the programs experienced an implantation rate of 19.9%, an implantation potential of 11.8%, and a live birth rate per embryo transferred of 15.0%. CONCLUSION(S): In this largest case series yet published, the pregnancy, delivery, and implantation rates for embryo donation compare favorably with rates reported from autologous IVF procedures.
Authors:
Jeffrey Keenan; Reginald Finger; Jerome H Check; Douglas Daly; William Dodds; Ron Stoddart
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-11-14
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1077-80     Citation Subset:  IM    
Affiliation:
National Embryo Donation Center, Knoxville, Tennessee 37934, USA.
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MeSH Terms
Descriptor/Qualifier:
Delivery, Obstetric / statistics & numerical data*
Embryo Transfer / statistics & numerical data*
Female
Fertilization in Vitro / statistics & numerical data*
Fetal Tissue Transplantation*
Humans
Incidence
Infertility / epidemiology*,  therapy*
Pregnancy
Pregnancy Outcome / epidemiology*
Treatment Outcome
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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