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Favorable outcome with doxorubicin-based chemotherapy and radiotherapy for adult patients with early stage primary systemic anaplastic large cell lymphoma.
MedLine Citation:
PMID:  23301725     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study was to analyze outcomes in adult patients with early stage systemic anaplastic large cell lymphoma (ALCL) treated with doxorubicin-based chemotherapy and radiotherapy. Forty-six adult patients with early stage systemic ALCL received chemotherapy followed by radiotherapy. All patients except two received chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) or a CHOP-like regimen. Twenty patients had stage I disease and 26 patients had stage II disease. The 5-year overall survival (OS), progression-free survival (PFS) and local control rates for all patients were 84.4%, 63.6%, and 90.8%, respectively. The 5-year OS and PFS rates were 95.0% and 77.4% for Ann Arbor stage I disease, and 75.1% and 51.7% for stage II disease, respectively. Lymph node involvement was the main pattern of disease progression or relapse for these patients. Adult patients with early stage systemic ALCL treated with doxorubicin-based chemotherapy and radiotherapy had a favorable prognosis. © 2013 John Wiley & Sons A/S.
Authors:
Xi-Mei Zhang; Ye-Xiong Li; Wei-Hu Wang; Jing Jin; Shu-Lian Wang; Yue-Ping Liu; Yong-Wen Song; Hua Ren; Hui Fang; Li-Qiang Zhou; Bo Chen; Shu-Nan Qi; Qing-Feng Liu; Ning-Ning Lu; Xin-Fan Liu; Zi-Hao Yu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Departments of Radiation Oncology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC).
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