Document Detail


Favourable metabolic effects of a eucaloric lower-carbohydrate diet in women with PCOS.
MedLine Citation:
PMID:  23444983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Diet-induced reduction in circulating insulin may be an attractive nonpharmacological treatment for women with polycystic ovary syndrome (PCOS) among whom elevated insulin may exacerbate symptoms by stimulating testosterone synthesis. This study was designed to determine whether a modest reduction in dietary carbohydrate (CHO) content affects β-cell responsiveness, serum testosterone concentration and insulin sensitivity in women with PCOS.
DESIGN: In a crossover design, two diets ('Standard,' STD, 55:18:27% energy from carbohydrate/protein/fat; lower-carbohydrate, 41:19:40) were provided for 8 weeks in random order with a 4-week washout between.
PATIENTS: Thirty women with PCOS.
MEASUREMENTS: β-cell responsiveness assessed as the C-peptide response to glucose during a liquid meal test; insulin sensitivity from insulin and glucose values throughout the test; insulin resistance (HOMA-IR); and total testosterone by immunoassay.
RESULTS: Paired t-test indicated that the lower-CHO diet induced significant decreases in basal β-cell response (PhiB), fasting insulin, fasting glucose, HOMA-IR, total testosterone and all cholesterol measures, and significant increases in insulin sensitivity and dynamic ('first-phase') β-cell response. The STD diet induced a decrease in HDL-C and an increase in the total cholesterol-to-HDL-C ratio. Across all data combined, the change in testosterone was positively associated with the changes in fasting insulin, PhiB and insulin AUC (P < 0·05).
CONCLUSIONS: In women with PCOS, modest reduction in dietary CHO in the context of a weight-maintaining diet has numerous beneficial effects on the metabolic profile that may lead to a decrease in circulating testosterone.
Authors:
Barbara A Gower; Paula C Chandler-Laney; Fernando Ovalle; Laura Lee Goree; Ricardo Azziz; Renee A Desmond; Wesley M Granger; Amy M Goss; G Wright Bates
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2013-05-20
Journal Detail:
Title:  Clinical endocrinology     Volume:  79     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-05     Completed Date:  2014-04-04     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-7     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Cross-Over Studies
Dietary Carbohydrates / administration & dosage*
Fasting / blood
Female
Humans
Insulin / blood,  metabolism*
Insulin Resistance
Insulin-Secreting Cells / metabolism*
Lipids / blood
Middle Aged
Outcome Assessment (Health Care)
Polycystic Ovary Syndrome / blood,  diet therapy*
Testosterone / blood
Young Adult
Grant Support
ID/Acronym/Agency:
P30 DK056336/DK/NIDDK NIH HHS; P30 DK079626/DK/NIDDK NIH HHS; P60 DK079626/DK/NIDDK NIH HHS; R01 HD054960/HD/NICHD NIH HHS; UL1 RR025777/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Insulin; 0/Lipids; 3XMK78S47O/Testosterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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