| Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. | |
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MedLine Citation:
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PMID: 20861175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epidemiologic evidence for the association between types of fatty acid and risk of type 2 diabetes is inconsistent. This may in part be due to the limitations of fatty acid measurement methods. OBJECTIVE: The objective was to use 3 different measures of fatty acid to estimate the prospective association between fatty acid composition and development of incident diabetes. DESIGN: We analyzed 199 cases of clinically incident diabetes and 184 noncases aged 40-79 y at baseline in the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study. Fatty acids were derived from a food-frequency questionnaire (FFQ) and measured in plasma phospholipid (P-FA) and erythrocyte-membrane phospholipid (Ery-FA) fractions by gas chromatography. RESULTS: There were stronger associations with diabetes risk with the use of objectively measured fatty acids (P-FA and Ery-FA) than with the FFQ in analyses adjusted for age, sex, and potential confounders. Positive associations with diabetes were greater in magnitude with the use of P-FA than with Ery-FA (highest:lowest tertiles): for example, the palmitic acid odds ratios (ORs) were 2.47 (95% CI: 1.37, 4.46) and 1.96 (95% CI: 1.10, 3.49), respectively. Inverse associations with diabetes were also stronger with the use of P-FA than with Ery-FA: for example, the OR for linoleic acid was 0.50 (95% CI: 0.28, 0.91) compared with 0.77 (95% CI: 0.43, 1.37), respectively. CONCLUSIONS: The objective measurement of fatty acids with the use of either P-FA or Ery-FA identifies important associations with diabetes incidence that may be missed when assessed by FFQ. Fatty acids measured in P-FA appear to be more strongly associated with diabetes incidence. These findings endorse the use of objective measurement of fatty acids for nutritional-epidemiologic studies, and the apparently stronger findings for the plasma fraction should be confirmed in larger studies and in different populations. |
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Authors:
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Pinal S Patel; Stephen J Sharp; Eugene Jansen; Robert N Luben; Kay-Tee Khaw; Nicholas J Wareham; Nita G Forouhi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-09-22 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1214-22 Citation Subset: AIM; IM |
Affiliation:
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Medical Research Council Epidemiology Unit, Cambridge, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Diabetes Mellitus, Type 2 / blood, etiology* Diet Records Dietary Fats / adverse effects* Erythrocyte Membrane / chemistry* Fatty Acids / adverse effects, blood* Female Humans Male Middle Aged Phospholipids / blood, chemistry* Pilot Projects Prospective Studies Questionnaires* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Cancer Research UK; //Department of Health; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Phospholipids |
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