Document Detail


Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis.
MedLine Citation:
PMID:  9543689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unsaturated long chain fatty acids modulate hormone secretion from a variety of endocrine glands, including the adrenal cortex. Oleic acid and linoleic acid have been shown to stimulate production of glucocorticoids in the absence of adrenocorticotropic hormone, but at a high concentration appeared to inhibit the action of this hormone. In the present study, the concentration dependence of the inhibitory actions of these two fatty acids was tested in collagenase-dispersed rat adrenal fasciculata cells, and the effects of both lipids on cAMP production were also determined. Adrenocorticotropic hormone stimulated steroid production from isolated cells approximately ten-fold above unstimulated cells. Oleic and linoleic acid significantly inhibited the response to this hormone by 44% and 54%, respectively. The half-maximally effective inhibitory concentration of both lipids was between 75-100 microM. A maximal concentration of adrenocorticotropic hormone increased cAMP secretion 138-fold above unstimulated cells. Oleic and linoleic acids inhibited the increase in cAMP secretion by 47% and 33%, respectively. It is concluded that pathophysiological concentrations of unsaturated fatty acids inhibit the action of adrenocorticotropic hormone on the adrenal gland, and that the mechanism of action of the lipids may be partly via inhibition of cAMP production.
Authors:
L A Matthys; E P Widmaier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  30     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-01     Completed Date:  1998-06-01     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  80-3     Citation Subset:  IM    
Affiliation:
University of Tennessee School of Medicine, Memphis, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / drug effects*
Adrenocorticotropic Hormone / antagonists & inhibitors*,  pharmacology
Animals
Cells, Cultured
Cyclic AMP / metabolism
Fatty Acids, Unsaturated / pharmacology*
Linoleic Acid / pharmacology
Male
Oleic Acid / pharmacology
Rats
Rats, Sprague-Dawley
Second Messenger Systems / physiology
Steroids / biosynthesis*
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Steroids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 60-92-4/Cyclic AMP; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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