Document Detail


Fatty acids-induced lipotoxicity and inflammation.
MedLine Citation:
PMID:  22978392     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fatty acids are known to serve as energetic substrates, key components of membrane lipids, and as substrates for the synthesis of signaling molecules and complex lipids. They are also known to be ligands either of membrane receptors involved in cell signaling or of nuclear receptors mediating gene regulation. Accumulation of fatty acids due to altered metabolism and/or unbalanced diet has been described to be toxic for several tissues, especially liver. In numerous cell types, cell death, cytokine secretion and activation of inflammatory processes appear to be a consequence of fatty acid accumulation. This review presents the different classes of fatty acids known trigger toxic effects and inflammation, the cellular and subcellular targets of these fatty acids in the context of non-alcoholic fatty liver disease (NAFLD), and the mechanisms by which these effects are mediated.
Authors:
Stéphane Savary; Doriane Trompier; Pierre Andréoletti; Françoise Le Borgne; Jean Demarquoy; Gérard Lizard
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-04
Journal Detail:
Title:  Current drug metabolism     Volume:  -     ISSN:  1875-5453     ISO Abbreviation:  Curr. Drug Metab.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960533     Medline TA:  Curr Drug Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Lab. Bio-PeroxIL, EA7270; University of Bourgogne 6 Bd Gabriel, Dijon, F-21000, France. gerard.lizard@u-bourgogne.fr.
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