| Fatty acids and idiopathic calcium nephrolithiasis. | |
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MedLine Citation:
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PMID: 16123560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible for calcium metabolism in idiopathic calcium nephrolithiasis, a best-fit model was constructed. This new statistical application shows a causal relationship between plasma phospholipid arachidonic acid content, intestinal calcium absorption, biochemical markers of bone turnover, urinary calcium excretion and bone mineral density at the lumbar spine. This model suggests that a defect in the phospholipid fatty acid composition could represent the primary event responsible for the mosaic of metabolic and clinical alterations that are distinctive features of renal stone formers, such as kidney, intestine, and bone calcium metabolism, and several forms of idiopathic hypercalciuria. |
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Authors:
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Bruno Baggio; Alessandro Budakovic |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Urologia internationalis Volume: 75 ISSN: 0042-1138 ISO Abbreviation: Urol. Int. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-26 Completed Date: 2005-12-08 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: Switzerland |
Other Details:
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Languages: eng Pagination: 97-101 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
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Department of Medical-Surgical Sciences, Division of Nephrology, University of Padua, Italy. bruno.baggio@unipd.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / urine Calcium Metabolism Disorders / complications*, diagnosis Disease Models, Animal Fatty Acids / metabolism* Humans Kidney Calculi / etiology*, metabolism*, physiopathology Risk Assessment Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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