| Fatty acids identified in the burmese python promote beneficial cardiac growth. | |
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MedLine Citation:
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PMID: 22034436 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Burmese pythons display a marked increase in heart mass after a large meal. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. We found that heart growth in pythons is characterized by myocyte hypertrophy in the absence of cell proliferation and by activation of physiological signal transduction pathways. Despite high levels of circulating lipids, the postprandial python heart does not accumulate triglycerides or fatty acids. Instead, there is robust activation of pathways of fatty acid transport and oxidation combined with increased expression and activity of superoxide dismutase, a cardioprotective enzyme. We also identified a combination of fatty acids in python plasma that promotes physiological heart growth when injected into either pythons or mice. |
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Authors:
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Cecilia A Riquelme; Jason A Magida; Brooke C Harrison; Christopher E Wall; Thomas G Marr; Stephen M Secor; Leslie A Leinwand |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 334 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 528-31 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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