Document Detail


Fatty acids and gene expression responses to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes.
MedLine Citation:
PMID:  22101882     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Effects of bioactive compounds on expression of genes involved in lipid metabolism and fatty acid composition were investigated in Atlantic salmon (Salmo salar L.) primary hepatocytes. METHODS: Five treatments were investigated: I) genistein 0.005 mM, II) genistein 0.025 mM, III) lipoic acid 0.2 mM, IV) sesamin/episesamin 0.05 mM, V) sesamin 0.05 mM and compared to controls. The relative expression of genes involved in lipid homeostasis was analysed after 12h and 48h. RESULTS: Incubation with lipoic acid, sesamin and episesamin/sesamin for 48h had significant effect on all analysed genes involved in lipid uptake, β-oxidation, elongation and desaturation, some effects were detected on the expression of peroxisome prolifertor-activated receptor (PPARs). Also effects on the fatty acid composition were found. CONCLUSION: The strongest effect of bioactive copounds on hepatocyte gene expression was detected after 48 hours.
Authors:
Anna Lotta Schiller Vestergren; Sofia Trattner; Jan Mraz; Bente Ruyter; Jana Pickova
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-21
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  32     ISSN:  0172-780X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  41-50     Citation Subset:  -    
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. Sofia.Trattner@slu.se.
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