| Fatty acids and gene expression responses to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes. | |
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MedLine Citation:
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PMID: 22101882 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: Effects of bioactive compounds on expression of genes involved in lipid metabolism and fatty acid composition were investigated in Atlantic salmon (Salmo salar L.) primary hepatocytes. METHODS: Five treatments were investigated: I) genistein 0.005 mM, II) genistein 0.025 mM, III) lipoic acid 0.2 mM, IV) sesamin/episesamin 0.05 mM, V) sesamin 0.05 mM and compared to controls. The relative expression of genes involved in lipid homeostasis was analysed after 12h and 48h. RESULTS: Incubation with lipoic acid, sesamin and episesamin/sesamin for 48h had significant effect on all analysed genes involved in lipid uptake, β-oxidation, elongation and desaturation, some effects were detected on the expression of peroxisome prolifertor-activated receptor (PPARs). Also effects on the fatty acid composition were found. CONCLUSION: The strongest effect of bioactive copounds on hepatocyte gene expression was detected after 48 hours. |
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Authors:
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Anna Lotta Schiller Vestergren; Sofia Trattner; Jan Mraz; Bente Ruyter; Jana Pickova |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 32 ISSN: 0172-780X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: - |
Other Details:
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Languages: ENG Pagination: 41-50 Citation Subset: - |
Affiliation:
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Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. Sofia.Trattner@slu.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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