| Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21328622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning public health concern in westernized nations. The obesity-related disorder is associated with an increased risk of cardiovascular disease, type 2 diabetes and liver failure. Although the underlying pathogenesis of NAFLD is unclear, increasing evidence suggests that excess saturated fatty acids presented to or stored within the liver may play a role in both the development and progression of the disorder. A putative mechanism linking saturated fatty acids to NAFLD may be endoplasmic reticulum (ER) stress. Specifically, excess saturated fatty acids may induce an ER stress response that, if left unabated, can activate stress signaling pathways, cause hepatocyte cell death, and eventually lead to liver dysfunction. In the current review we discuss the involvement of saturated fatty acids in the pathogenesis of NAFLD with particular emphasis on the role of ER stress. |
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Authors:
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Christopher L Gentile; Melinda A Frye; Michael J Pagliassotti |
Publication Detail:
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Type: Journal Article; Review Date: 2010-12-02 |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 37 ISSN: 1872-8081 ISO Abbreviation: Biofactors Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-06-06 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 8-16 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc. |
Affiliation:
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Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Endoplasmic Reticulum / metabolism* Fatty Acids / metabolism* Fatty Liver / metabolism, pathology Humans Intracellular Signaling Peptides and Proteins / metabolism Stress, Physiological Unfolded Protein Response |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK047416-13/DK/NIDDK NIH HHS; R01 DK072017-05A1/DK/NIDDK NIH HHS; R56 DK072017-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Intracellular Signaling Peptides and Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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