Document Detail

Fatty acids as markers of the blood-cerebrospinal fluid barrier function in man.
MedLine Citation:
PMID:  8406137     Owner:  NLM     Status:  MEDLINE    
The blood-cerebrospinal fluid barrier (BCB) function in man is derived from the CSF:serum ratio of albumin (QAlb). In order to study other than BCB protein transport we compared CSF:serum ratios of fatty acids in patients revealing normal and increased QAlb values. Ratios of unsaturated fatty acids, which are involved in inflammation, increased significantly in patients with increased QAlb (p < 0.005). In contrast, CSF:serum ratios of saturated fatty acids increased only slightly. We conclude that characterisation of BCB lipid properties may be of particular interest regarding drug penetration into the CSF and lipid metabolism in inflammation.
U Roelcke; J Heil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Functional neurology     Volume:  8     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-11-17     Completed Date:  1993-11-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Department of Neurology, University of Heidelberg, Germany.
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MeSH Terms
Blood-Brain Barrier / physiology*
Central Nervous System Diseases / cerebrospinal fluid*,  diagnosis
Fatty Acids / cerebrospinal fluid*
Middle Aged
Reference Values
Serum Albumin / cerebrospinal fluid
Reg. No./Substance:
0/Fatty Acids; 0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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