Document Detail


Fatty acid transport across the cell membrane: regulation by fatty acid transporters.
MedLine Citation:
PMID:  20206486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transport of long-chain fatty acids across the cell membrane has long been thought to occur by passive diffusion. However, in recent years there has been a fundamental shift in understanding, and it is now generally recognized that fatty acids cross the cell membrane via a protein-mediated mechanism. Membrane-associated fatty acid-binding proteins ('fatty acid transporters') not only facilitate but also regulate cellular fatty acid uptake, for instance through their inducible rapid (and reversible) translocation from intracellular storage pools to the cell membrane. A number of fatty acid transporters have been identified, including CD36, plasma membrane-associated fatty acid-binding protein (FABP(pm)), and a family of fatty acid transport proteins (FATP1-6). Fatty acid transporters are also implicated in metabolic disease, such as insulin resistance and type-2 diabetes. In this report we briefly review current understanding of the mechanism of transmembrane fatty acid transport, and the function of fatty acid transporters in healthy cardiac and skeletal muscle, and in insulin resistance/type-2 diabetes. Fatty acid transporters hold promise as a future target to rectify lipid fluxes in the body and regain metabolic homeostasis.
Authors:
Robert W Schwenk; Graham P Holloway; Joost J F P Luiken; Arend Bonen; Jan F C Glatz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-04
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  82     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD36 / physiology
Biological Transport / physiology
Cell Membrane / metabolism*
Fatty Acid Transport Proteins / physiology*
Fatty Acid-Binding Proteins / physiology
Fatty Acids / pharmacokinetics*
Glucose Transporter Type 4 / physiology
Humans
Mice
Models, Biological
Muscles / metabolism*
Rats
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/FATP4 protein, rat; 0/Fatty Acid Transport Proteins; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Glucose Transporter Type 4; 0/Slc27a1 protein, rat

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