Document Detail


Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?
MedLine Citation:
PMID:  22009142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has long been categorized as a housekeeping protein, producing fat for storage of energy when nutrients are present in excess. Most previous studies of FAS regulation have focused on the control of gene expression. However, recent findings suggest that hepatic FAS may also be involved in signaling processes that include activation of peroxisome proliferator-activated receptor α (PPARα). Moreover, reports of rapid alterations in FAS activity as well as findings of post-translational modifications of the FAS protein support the notion that dynamic events in addition to transcription impact FAS regulation. These results indicate that FAS enzyme activity can impact liver physiology through signaling as well as energy storage and that its regulation may be complex. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.
Authors:
Anne P L Jensen-Urstad; Clay F Semenkovich
Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-08
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1821     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-11-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  747-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Fatty Acid Synthetase Complex / genetics,  metabolism*
Fatty Acids / biosynthesis,  metabolism
Gene Expression
Humans
Liver / enzymology*
Molecular Sequence Data
PPAR alpha / metabolism*
Protein Processing, Post-Translational
Signal Transduction*
Triglycerides / metabolism*
Grant Support
ID/Acronym/Agency:
R01 DK076729/DK/NIDDK NIH HHS; R01 DK076729-04/DK/NIDDK NIH HHS; R01 DK088083/DK/NIDDK NIH HHS; R01 DK088083-02/DK/NIDDK NIH HHS; R01 DK088083-03/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/PPAR alpha; 0/Triglycerides; EC 6.-/Fatty Acid Synthetase Complex
Comments/Corrections

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