Document Detail

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.
MedLine Citation:
PMID:  220968     Owner:  NLM     Status:  MEDLINE    
The hydrolysis of membrane-bound phosphatidylinositol in rat liver microsomal fraction by the soluble phosphatidylinositol phosphodiesterase from rat brain was markedly stimulated by oleic acid or arachidonic acid. The stimulation did not require added calcium, although it was abolished by EDTA. Lysophosphatidylcholine also totally suppressed the stimulation. A possible role for the fatty acid content of a membrane in controlling phosphatidylinositol turnover is suggested.
R F Irvine; A J Letcher; R M Dawson
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  178     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  497-500     Citation Subset:  IM    
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MeSH Terms
Brain / enzymology
Cell Membrane / metabolism*
Fatty Acids / pharmacology*
Intracellular Membranes / metabolism
Microsomes, Liver / metabolism
Phosphatidylinositols / metabolism*
Phosphoric Diester Hydrolases / metabolism*
Stimulation, Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phosphatidylinositols; EC 3.1.4.-/Phosphoric Diester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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