Document Detail

Fatty acid profiles of rat renal phospholipids during development.
MedLine Citation:
PMID:  9096895     Owner:  NLM     Status:  MEDLINE    
The fatty acid content of rat renal phospholipids was examined during development. An increase in the arachidonic acid content of a particular fraction of phosphatidylcholine (PC2), phosphatidylethanolamine and phosphatidylinositol between 10 and 20 days of age could be observed in the papilla, and these levels were maintained into adulthood, while in the 20:4 content of phosphatidylserine changes were found between 30-day-old rats and adults. In the other fraction of phosphatidylcholine (PC1), saturated fatty acids such as 16:0 and 14:0 decreased, while no changes occurred in the stearic acid (18:0) content. The pattern found for the medulla did not differ significantly from that of the papilla. In contrast, the cortex content of arachidonic acid at 10 days of age was higher than that for papilla and medulla. Levels increased between 10 and 20 days of age, returning to the original values by 30 days with no further variations in the adult. These changes in arachidonic acid content with age in addition to the differences found between the three kidney zones might explain some causes of incomplete renal function in newborns.
C L D'Antuono; N B Sterin-Speziale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  71     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  162-70     Citation Subset:  IM    
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, UBA, Buenos Aires, Argentina.
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MeSH Terms
Aging / metabolism*
Analysis of Variance
Animals, Newborn
Arachidonic Acid / analysis
Chromatography, Gas
Fatty Acids / analysis*
Kidney / growth & development,  metabolism*
Kidney Cortex / metabolism
Kidney Medulla / metabolism
Phosphatidylcholines / chemistry,  metabolism
Phosphatidylethanolamines / chemistry,  metabolism
Phosphatidylinositols / chemistry,  metabolism
Phosphatidylserines / chemistry,  metabolism
Phospholipids / chemistry,  metabolism*
Rats, Wistar
Reg. No./Substance:
0/Fatty Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylinositols; 0/Phosphatidylserines; 0/Phospholipids; 506-32-1/Arachidonic Acid

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