Document Detail


Fatty acid profiles of plasmalogen choline and ethanolamine glycerophospholipids in pig and rat hearts.
MedLine Citation:
PMID:  8833966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of relatively high concentrations of plasmalogen choline and ethanolamine in the heart of many animal species suggests a role of these ether-linked phospholipids in the pathophysiology of certain myocardial diseases. However, the fatty acid composition of myocardial plasmalogens in many species is not known. This study examined the fatty acid composition of the choline and ethanolamine glycerophospholipids in pig heart and compared the results with those in rat heart. Lipids were extracted from the heart biopsies obtained from pig and rat by standard techniques. Phosphoglycerides were separated by thin-layer chromatography followed by their derivatization into fatty acid methyl esters (FAMEs) and dimethyl acetals (DMAs). FAME and DMA samples were analyzed using gas chromatography-mass spectroscopy. Our results indicate striking differences in the fatty acid composition of both choline and ethanolamine glycerophosphates between rat heart and pig heart. Pig heart ethanolamine glycerophosphates are rich in linoleic acid (18:2) and arachidonic acid (20:4), but low in descosahexenoic (22:6) fatty acids while choline glycerophosphates are poor in both 20:4 and 22:6 fatty acids compared to those in rat hearts.
Authors:
N Maulik; D Bagchi; W J Ihm; G A Cordis; D K Das
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  14     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Affiliation:
University of Connecticut School of Medicine, Farmington 06030-1110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gas
Fatty Acids / analysis*
Gas Chromatography-Mass Spectrometry
Male
Myocardium / chemistry*
Phosphatidylethanolamines / analysis*
Plasmalogens / analysis*
Rats
Rats, Sprague-Dawley
Swine
Grant Support
ID/Acronym/Agency:
HL 22 559/HL/NHLBI NIH HHS; HL 34 360/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phosphatidylethanolamines; 0/Plasmalogens; 0/choline plasmalogens

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