| Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. | |
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MedLine Citation:
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PMID: 14620617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Polyunsaturated fatty acids, as precursors of eicosanoids, are involved in the pathogenesis of oesophageal mucosal damage and healing. AIMS: To evaluate a possible role of polyunsaturated fatty acids in the pathogenesis of gastro-oesophageal reflux, we assayed fatty acids profile of oesophageal mucosal specimens obtained by endoscopy in children without oesophageal disease and children affected by gastro-oesophageal reflux disease. PATIENTS: Eighteen children with normal 24-h oesophageal pH monitoring (GOR- group) and 18 children with gastro-oesophageal reflux disease (GOR+ group, eight with oesophagitis and 10 without), were included in the study. METHODS: Fatty acids were extracted from oesophageal mucosal specimens obtained by endoscopy and assayed by gas chromatography. RESULTS: In the GOR+ group we observed an increased percentage of mucosal polyunsaturated fatty acids, mainly arachidonic and docosohexaenoic acids (p<0.01), without differences between groups with and without oesophagitis. Significant positive correlation was found between reflux index and docosahexaenoic acid (r=0.805; p<0.001). CONCLUSIONS: The results obtained show that the current methods are able to reveal changes between normal and pathological mucosa that could be relevant in the pathogenesis of gastro-oesophageal reflux disease. |
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Authors:
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P D'Eufemia; M Celli; R Finocchiaro; P Troiani; J Tote; O Giardini; G Corrado |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 35 ISSN: 1590-8658 ISO Abbreviation: Dig Liver Dis Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 694-700 Citation Subset: IM |
Affiliation:
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Department of Paedriatics, La Sapienza University, Viale Regina Elena, 324-00161 Rome, Italy. patdeufemia@inwind.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid
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metabolism Case-Control Studies Child Chromatography, Gas Docosahexaenoic Acids / metabolism Environmental Monitoring Esophagitis, Peptic / metabolism Esophagoscopy Esophagus / metabolism* Fatty Acids, Unsaturated / metabolism* Female Gastroesophageal Reflux / etiology, metabolism* Humans Hydrogen-Ion Concentration Male Mucous Membrane / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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