Document Detail

Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease.
MedLine Citation:
PMID:  14620617     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Polyunsaturated fatty acids, as precursors of eicosanoids, are involved in the pathogenesis of oesophageal mucosal damage and healing. AIMS: To evaluate a possible role of polyunsaturated fatty acids in the pathogenesis of gastro-oesophageal reflux, we assayed fatty acids profile of oesophageal mucosal specimens obtained by endoscopy in children without oesophageal disease and children affected by gastro-oesophageal reflux disease. PATIENTS: Eighteen children with normal 24-h oesophageal pH monitoring (GOR- group) and 18 children with gastro-oesophageal reflux disease (GOR+ group, eight with oesophagitis and 10 without), were included in the study. METHODS: Fatty acids were extracted from oesophageal mucosal specimens obtained by endoscopy and assayed by gas chromatography. RESULTS: In the GOR+ group we observed an increased percentage of mucosal polyunsaturated fatty acids, mainly arachidonic and docosohexaenoic acids (p<0.01), without differences between groups with and without oesophagitis. Significant positive correlation was found between reflux index and docosahexaenoic acid (r=0.805; p<0.001). CONCLUSIONS: The results obtained show that the current methods are able to reveal changes between normal and pathological mucosa that could be relevant in the pathogenesis of gastro-oesophageal reflux disease.
P D'Eufemia; M Celli; R Finocchiaro; P Troiani; J Tote; O Giardini; G Corrado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  35     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  IM    
Department of Paedriatics, La Sapienza University, Viale Regina Elena, 324-00161 Rome, Italy.
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MeSH Terms
Arachidonic Acid / metabolism
Case-Control Studies
Chromatography, Gas
Docosahexaenoic Acids / metabolism
Environmental Monitoring
Esophagitis, Peptic / metabolism
Esophagus / metabolism*
Fatty Acids, Unsaturated / metabolism*
Gastroesophageal Reflux / etiology,  metabolism*
Hydrogen-Ion Concentration
Mucous Membrane / metabolism
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

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