Document Detail

Fatty acid patterns in parenterally fed premature and term infants: changes induced by intralipid and sunflower seed oil.
MedLine Citation:
PMID:  2506874     Owner:  NLM     Status:  MEDLINE    
In order to prevent the development of essential fatty acid deficiency, 19 premature babies and term infants needing parenteral nutrition were studied during 14 days. Intralipid 20% was administered to ten and sunflower seed oil was rubbed six times daily on the skin of nine infants. Fatty acid pattern of plasma lipids were determined at birth and days 7 and 14. Levels of C16:0, C18:1, C18:2, and C20:4 did not change in the Intralipid group. In the sunflower seed oil group a decrease in C18:2 developed, which could be corrected by administering Intralipid (Intralipid was administered to four patients who had previously received sunflower seed oil during 14 days). Although Intralipid administration is often controversial or contraindicated in premature infants (hypoxia, septicemia, acidemia), it appears necessary to prevent plasmatic deficiency in C18:2. The latter cannot be prevented by topical application of sunflower seed oil, not even in very low birthweight infants.
Y Vandenplas; L Leyssens; A Bougatef; L Sacre; B François
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  6     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-07     Completed Date:  1989-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  393-6     Citation Subset:  IM    
Academic Childrens Hospital, Free University of Brussels, Belgium.
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MeSH Terms
Administration, Cutaneous
Double-Blind Method
Fat Emulsions, Intravenous / administration & dosage*
Fatty Acids / blood*
Fatty Acids, Essential / blood,  deficiency*
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood,  prevention & control*
Parenteral Nutrition*
Plant Oils / administration & dosage*
Prospective Studies
Random Allocation
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Plant Oils; 8001-21-6/sunflower seed oil

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