Document Detail


Fatty acid metabolism in renal ischemia.
MedLine Citation:
PMID:  3185124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increase in free fatty acids in the ischemic tissue is a consistent observation and these free fatty acids are considered to play a role in the cellular toxicity. To elucidate the cause of higher levels of free fatty acids in ischemic tissue, we examined the catabolism of fatty acids. The beta-oxidation of lignoceric (24:0), palmitic (16:0) and octanoic (8:0) acids and the peroxidation of fatty acids were measured at different times of renal ischemia in whole kidney homogenate. The enzymatic activities for the oxidation of fatty acids decreased with the increase in ischemia time. However, the lipid peroxide levels increased 2.5-fold of control with ischemic injury. Sixty min of ischemia reduced the rate of oxidation of octanoic, palmitic and lignoceric acids by 57, 59 and 69%, respectively. Almost similar loss of fatty acid oxidation activity was observed in the peroxisomes and mitochondria. These data suggest that loss of mitochondrial and peroxisomal fatty acid beta-oxidation enzyme activities from ischemic injury may be one of the factors responsible for the higher levels of free fatty acids.
Authors:
E Ruidera; C E Irazu; P R Rajagopalan; J K Orak; C T Fitts; I Singh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  23     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  882-4     Citation Subset:  IM    
Affiliation:
Medical University of South Carolina, Charleston 29425.
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids / metabolism*
Fatty Acids, Nonesterified / metabolism
Ischemia
Kidney / blood supply*
Male
Octanoic Acids / metabolism
Oxidation-Reduction
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
NS 22576/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Octanoic Acids; 124-07-2/caprylic acid; 557-59-5/lignoceric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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