Document Detail

Fatty acid metabolism in neonatal chickens (Gallus domesticus) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3',4,4',5-pentachlorobiphenyl (PCB-126) in ovo.
MedLine Citation:
PMID:  14522600     Owner:  NLM     Status:  MEDLINE    
Treatment of chickens as pre-incubation embryos with TCDD or PCB-126 altered fatty acid concentrations in their plasma 21 days later, compared with their oil vehicles (sunflower and corn oils, respectively). TCDD increased the concentrations of total fatty acids, lipid classes (phospholipids and cholesterol ester), fatty acid families (saturated, n-7 and n-6), and many specific fatty acids. The only fatty acid concentrations decreased by TCDD treatment were those of cholesterol ester fatty acids 20:3n3 and 24:6n3 and overall plasma 24:6n3. In contrast, PCB-126 treatment decreased total phospholipid, saturated and plasmogen fatty acid concentrations with generally decreasing trends in specific fatty acid concentrations. However, both TCDD and PCB-126 treatments increased total 22:1n9 and decreased 24:6n3 concentrations compared with their respective vehicles. The potential relationship between those fatty acid concentrations altered by toxicant treatment and alterations in brain symmetry was then examined using correlation analysis. Several fatty acid concentrations were significantly correlated with differences in brain morphology between the right and left hemispheres and these potential associations were different between toxicant and vehicle.
Beckye Stanton; Jamie DeWitt; Diane Henshel; Steven Watkins; Bill Lasley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  136     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-02     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-84     Citation Subset:  IM    
Center for Health and the Environment, University of California, Davis, CA 95616, USA.
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MeSH Terms
Abnormalities, Drug-Induced
Brain / abnormalities,  drug effects
Chick Embryo
Chickens / metabolism*
Embryonic and Fetal Development / drug effects,  physiology
Estrogen Antagonists / toxicity*
Fatty Acids / metabolism*
Polychlorinated Biphenyls / toxicity*
Teratogens / toxicity*
Tetrachlorodibenzodioxin / toxicity*
Reg. No./Substance:
0/Estrogen Antagonists; 0/Fatty Acids; 0/Polychlorinated Biphenyls; 0/Teratogens; 1746-01-6/Tetrachlorodibenzodioxin; 57465-28-8/3,4,5,3',4'-pentachlorobiphenyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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