Document Detail


Fatty acid metabolism in liver of dairy cows fed supplemental fat and nicotinic acid during an entire lactation.
MedLine Citation:
PMID:  12487468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver biopsies from 38 multiparous Holstein cows were used to determine rates of peroxisomal beta-oxidation and total beta-oxidation of palmitate in liver homogenates and contents of total lipid, triglyceride, and glycogen during the lactation cycle. Cows were assigned to one of four diets from wk 4 through wk 42 of lactation: control, control plus nicotinic acid (12 g/d), supplemental fat, or supplemental fat plus nicotinic acid. Liver biopsies were obtained at wk 3 (covariate), 6, 12, 24, and 42 of lactation. Neither supplemental fat nor nicotinic acid affected palmitate oxidation in liver homogenates or liver composition. Peroxisomal beta-oxidation capacity and the ratio of peroxisomal to total beta-oxidation decreased from wk 3 to 12 and then increased at wk 42. Contents of total lipid and triglyceride decreased, and content of glycogen increased, from wk 3 to 12. Total oxidation capacity in liver homogenates was correlated negatively with total lipid and triglyceride in liver, yields of milk and solids-corrected milk (SCM), and plasma nonesterified fatty acids (NEFA), and was correlated positively with liver glycogen, dry matter intake (DMI), energy balance, and plasma glucose. Peroxisomal beta-oxidation was correlated negatively with yields of milk and SCM. The ratio of peroxisomal to total beta-oxidation was correlated positively with liver total lipid, liver TG, and plasma NEFA and negatively with DMI and energy balance. When only data from wk 3 postpartum were considered, both total and peroxisomal beta-oxidation were correlated negatively with hepatic concentrations of total lipid and TG. Peroxisomal beta-oxidation in liver of dairy cows is not affected by feeding supplemental fat or nicotinic acid during wk 4 to 42 of lactation but may be a part of the hepatic adaptations to negative energy balance.
Authors:
D E Grum; J K Drackley; J H Clark
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of dairy science     Volume:  85     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-18     Completed Date:  2003-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3026-34     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences, University of Illinois, Urbana 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle / metabolism,  physiology*
Dietary Fats / administration & dosage*,  metabolism
Fatty Acids / metabolism
Fatty Acids, Nonesterified / blood
Female
Glycogen / metabolism
Lactation
Lipid Metabolism
Liver / metabolism*,  pathology
Milk / chemistry,  secretion
Niacin / administration & dosage*,  metabolism
Oxidation-Reduction
Palmitates / metabolism*
Peroxisomes / metabolism
Random Allocation
Time Factors
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Palmitates; 0/Triglycerides; 59-67-6/Niacin; 9005-79-2/Glycogen
Comments/Corrections
Erratum In:
J Dairy Sci. 2002 Dec;85(12):Follows table of contents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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