| Fatty acid metabolism in liver of dairy cows fed supplemental fat and nicotinic acid during an entire lactation. | |
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MedLine Citation:
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PMID: 12487468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liver biopsies from 38 multiparous Holstein cows were used to determine rates of peroxisomal beta-oxidation and total beta-oxidation of palmitate in liver homogenates and contents of total lipid, triglyceride, and glycogen during the lactation cycle. Cows were assigned to one of four diets from wk 4 through wk 42 of lactation: control, control plus nicotinic acid (12 g/d), supplemental fat, or supplemental fat plus nicotinic acid. Liver biopsies were obtained at wk 3 (covariate), 6, 12, 24, and 42 of lactation. Neither supplemental fat nor nicotinic acid affected palmitate oxidation in liver homogenates or liver composition. Peroxisomal beta-oxidation capacity and the ratio of peroxisomal to total beta-oxidation decreased from wk 3 to 12 and then increased at wk 42. Contents of total lipid and triglyceride decreased, and content of glycogen increased, from wk 3 to 12. Total oxidation capacity in liver homogenates was correlated negatively with total lipid and triglyceride in liver, yields of milk and solids-corrected milk (SCM), and plasma nonesterified fatty acids (NEFA), and was correlated positively with liver glycogen, dry matter intake (DMI), energy balance, and plasma glucose. Peroxisomal beta-oxidation was correlated negatively with yields of milk and SCM. The ratio of peroxisomal to total beta-oxidation was correlated positively with liver total lipid, liver TG, and plasma NEFA and negatively with DMI and energy balance. When only data from wk 3 postpartum were considered, both total and peroxisomal beta-oxidation were correlated negatively with hepatic concentrations of total lipid and TG. Peroxisomal beta-oxidation in liver of dairy cows is not affected by feeding supplemental fat or nicotinic acid during wk 4 to 42 of lactation but may be a part of the hepatic adaptations to negative energy balance. |
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Authors:
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D E Grum; J K Drackley; J H Clark |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of dairy science Volume: 85 ISSN: 0022-0302 ISO Abbreviation: J. Dairy Sci. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-18 Completed Date: 2003-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985126R Medline TA: J Dairy Sci Country: United States |
Other Details:
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Languages: eng Pagination: 3026-34 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, University of Illinois, Urbana 61801, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle / metabolism, physiology* Dietary Fats / administration & dosage*, metabolism Fatty Acids / metabolism Fatty Acids, Nonesterified / blood Female Glycogen / metabolism Lactation Lipid Metabolism Liver / metabolism*, pathology Milk / chemistry, secretion Niacin / administration & dosage*, metabolism Oxidation-Reduction Palmitates / metabolism* Peroxisomes / metabolism Random Allocation Time Factors Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Palmitates; 0/Triglycerides; 59-67-6/Niacin; 9005-79-2/Glycogen |
| Comments/Corrections | |
Erratum In:
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J Dairy Sci. 2002 Dec;85(12):Follows table of contents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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