Document Detail

Fatty acid metabolism in health and disease: the role of delta-6-desaturase.
MedLine Citation:
PMID:  8386433     Owner:  NLM     Status:  MEDLINE    
Linoleic acid is the main dietary essential fatty acid (EFA). To be fully utilized by the body, it must be metabolized to a range of other substances. The first step in this pathway is delta-6-desaturation to gamma-linolenic acid (GLA). This step is slow and rate-limiting, particularly in humans. If delta-6-desaturation is impaired for any reason, the supply of further metabolites may be inadequate for normal function. If the consumption of further metabolites is excessive, then a normal rate of delta-6-desaturation may be inadequate. In these circumstances the direct supply of GLA or further metabolites may be of value. This concept is illustrated by atopic eczema and diabetes, which may represent inherited and acquired examples of inadequate delta-6-desaturation.
D F Horrobin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  57     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-05-14     Completed Date:  1993-05-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  732S-736S; discussion 736S-737S     Citation Subset:  AIM; IM    
Efamol Research Institute, Kentville, Nova Scotia, Canada.
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MeSH Terms
Dermatitis, Atopic / blood,  metabolism*
Diabetes Mellitus / blood,  metabolism*
Diabetic Neuropathies / prevention & control
Fatty Acid Desaturases / blood*
Fatty Acids, Essential / blood,  metabolism*
Linoleic Acid
Linoleic Acids / blood
Linolenic Acids / administration & dosage,  blood,  metabolism
Linoleoyl-CoA Desaturase
gamma-Linolenic Acid
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Linolenic Acids; 2197-37-7/Linoleic Acid; 506-26-3/gamma-Linolenic Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC Desaturase

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