| Fatty acid ethyl esters in meconium are associated with poorer neurodevelopmental outcomes to two years of age. | |
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MedLine Citation:
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PMID: 18492517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the relationship between fatty acid ethyl esters (FAEE) in meconium and neurodevelopment in infants exposed to alcohol in utero at 6.5 months, 1 year, and 2 years of age. STUDY DESIGN: A secondary analysis of a prospective cohort of mothers at high risk and their infants recruited after admission to a labor and delivery unit. Mothers were screened for drug and alcohol use during pregnancy by clinical interview and urine screening. Meconium was analyzed for FAEE in 216 newborn infants. Outcome measures included the Bayley Scales of Infant Development Mental (MDI) and Psychomotor (PDI) Developmental Index scores in infants at 6.5 months, 1 year, and 2 years of age. RESULTS: After controlling for prenatal visits and maternal factors, increasing concentrations of FAEE were significantly associated with poorer mental and psychomotor development (beta +/- standard error) at all follow-up visits: ethyl myristate (MDI -2.46 +/- 1.24, P = .05; PDI -3.88 +/- 1.67, P = .02), ethyl oleate (MDI -1.94 +/- 0.65, P < .01; PDI -2.60 +/- 0.93, P < .01), ethyl linoleate (MDI -1.92 +/- 0.60, P < .01; PDI -2.28 +/- 0.84, P < .01), ethyl linolenate (MDI -1.99 +/- 0.74, P < .01; PDI -2.98 +/- 1.04, P < .01), and ethyl arachidonate (MDI -2.40 +/- 1.11, P = .03; PDI -3.32 +/- 1.51, P = .03). CONCLUSION: FAEE in meconium may be a marker for identifying newborns at risk for neurodevelopmental delay from alcohol exposure in utero. |
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Authors:
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Jennifer Peterson; H Lester Kirchner; Wei Xue; Sonia Minnes; Lynn T Singer; Cynthia F Bearer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2008-01-10 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 152 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-21 Completed Date: 2008-07-25 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 788-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. petersj2@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acids
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analysis Child, Preschool Developmental Disabilities / epidemiology* Follow-Up Studies Humans Infant Linoleic Acids / analysis Linolenic Acids / analysis Meconium / chemistry* Myristates / analysis Oleic Acids / analysis Palmitic Acids / analysis Prognosis Prospective Studies Psychomotor Performance |
| Grant Support | |
ID/Acronym/Agency:
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MM-0122-02/02//PHS HHS; NIDA R01-07957//PHS HHS; P01 ES011261-010002/ES/NIEHS NIH HHS; P01 ES011261-020002/ES/NIEHS NIH HHS; P01 ES011261-030002/ES/NIEHS NIH HHS; P01 ES011261-040002/ES/NIEHS NIH HHS; P01 ES011261-050002/ES/NIEHS NIH HHS; P01 ES11261/ES/NIEHS NIH HHS; R01 DA007957-06/DA/NIDA NIH HHS; R03 AA012618-01/AA/NIAAA NIH HHS; R03 AA012618-02/AA/NIAAA NIH HHS; R03 AA12618/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Linoleic Acids; 0/Linolenic Acids; 0/Myristates; 0/Oleic Acids; 0/Palmitic Acids; 111-62-6/ethyl oleate; 1191-41-9/ethyl linolenate; 124-06-1/ethyl myristate; 1808-26-0/ethyl arachidonate; 544-35-4/ethyl linoleate; 628-97-7/ethyl palmitate |
| Comments/Corrections | |
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