Document Detail

Fatty acid ethyl esters in meconium are associated with poorer neurodevelopmental outcomes to two years of age.
MedLine Citation:
PMID:  18492517     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between fatty acid ethyl esters (FAEE) in meconium and neurodevelopment in infants exposed to alcohol in utero at 6.5 months, 1 year, and 2 years of age.
STUDY DESIGN: A secondary analysis of a prospective cohort of mothers at high risk and their infants recruited after admission to a labor and delivery unit. Mothers were screened for drug and alcohol use during pregnancy by clinical interview and urine screening. Meconium was analyzed for FAEE in 216 newborn infants. Outcome measures included the Bayley Scales of Infant Development Mental (MDI) and Psychomotor (PDI) Developmental Index scores in infants at 6.5 months, 1 year, and 2 years of age.
RESULTS: After controlling for prenatal visits and maternal factors, increasing concentrations of FAEE were significantly associated with poorer mental and psychomotor development (beta +/- standard error) at all follow-up visits: ethyl myristate (MDI -2.46 +/- 1.24, P = .05; PDI -3.88 +/- 1.67, P = .02), ethyl oleate (MDI -1.94 +/- 0.65, P < .01; PDI -2.60 +/- 0.93, P < .01), ethyl linoleate (MDI -1.92 +/- 0.60, P < .01; PDI -2.28 +/- 0.84, P < .01), ethyl linolenate (MDI -1.99 +/- 0.74, P < .01; PDI -2.98 +/- 1.04, P < .01), and ethyl arachidonate (MDI -2.40 +/- 1.11, P = .03; PDI -3.32 +/- 1.51, P = .03).
CONCLUSION: FAEE in meconium may be a marker for identifying newborns at risk for neurodevelopmental delay from alcohol exposure in utero.
Jennifer Peterson; H Lester Kirchner; Wei Xue; Sonia Minnes; Lynn T Singer; Cynthia F Bearer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2008-01-10
Journal Detail:
Title:  The Journal of pediatrics     Volume:  152     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-07-25     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-92     Citation Subset:  AIM; IM    
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MeSH Terms
Arachidonic Acids / analysis
Child, Preschool
Developmental Disabilities / epidemiology*
Follow-Up Studies
Linoleic Acids / analysis
Linolenic Acids / analysis
Meconium / chemistry*
Myristates / analysis
Oleic Acids / analysis
Palmitic Acids / analysis
Prospective Studies
Psychomotor Performance
Grant Support
MM-0122-02/02//PHS HHS; NIDA R01-07957//PHS HHS; P01 ES011261/ES/NIEHS NIH HHS; P01 ES011261-010002/ES/NIEHS NIH HHS; P01 ES011261-020002/ES/NIEHS NIH HHS; P01 ES011261-030002/ES/NIEHS NIH HHS; P01 ES011261-040002/ES/NIEHS NIH HHS; P01 ES011261-050002/ES/NIEHS NIH HHS; P01 ES11261/ES/NIEHS NIH HHS; R01 DA007957/DA/NIDA NIH HHS; R01 DA007957-06/DA/NIDA NIH HHS; R03 AA012618/AA/NIAAA NIH HHS; R03 AA012618-01/AA/NIAAA NIH HHS; R03 AA012618-02/AA/NIAAA NIH HHS; R03 AA12618/AA/NIAAA NIH HHS
Reg. No./Substance:
0/Arachidonic Acids; 0/Linoleic Acids; 0/Linolenic Acids; 0/Myristates; 0/Oleic Acids; 0/Palmitic Acids; 3NU6034AW3/ethyl arachidonate; 6995S49749/ethyl myristate; IRD3M534ZM/ethyl palmitate; MJ2YTT4J8M/ethyl linoleate; T54Y8H042V/ethyl linolenate; Z2Z439864Y/ethyl oleate

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