Document Detail


Fatty acid cycling mechanism and mitochondrial uncoupling proteins.
MedLine Citation:
PMID:  9693744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesize that fatty acid-induced uncoupling serves in bioenergetic systems to set the optimum efficiency and tune the degree of coupling of oxidative phosphorylation. Uncoupling results from fatty acid cycling, enabled by several phylogenetically specialized proteins and, to a lesser extent, by other mitochondrial carriers. It is suggested that the regulated uncoupling in mammalian mitochondria is provided by uncoupling proteins UCP-1, UCP-2 and UCP-3, whereas in plant mitochondria by PUMP and StUCP, all belonging to the gene family of mitochondrial carriers. UCP-1, and hypothetically UCP-3, serve mostly to provide nonshivering thermogenesis in brown adipose tissue and skeletal muscle, respectively. Fatty acid cycling was documented for UCP-1, PUMP and ADP/ATP carrier, and is predicted also for UCP-2 and UCP-3. UCP-1 mediates a purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids. The return of protonated fatty acid leads to H+ uniport and uncoupling. UCP-2 is probably involved in the regulation of body weight and energy balance, in fever, and defense against generation of reactive oxygen species. PUMP has been discovered in potato tubers and immunologically detected in fruits and corn, whereas StUCP has been cloned and sequenced froma a potato gene library. PUMP is supposed to act in the termination of synthetic processes in mature fruits and during the climacteric respiratory rise.
Authors:
P Jezek; H Engstová; M Zácková; A E Vercesi; A D Costa; P Arruda; K D Garlid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1365     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
Affiliation:
Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague. jezek@sun1.biomed.cas.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / metabolism*
Energy Metabolism
Fatty Acids / metabolism*
Humans
Ion Channels
Membrane Proteins / metabolism*
Mitochondria, Heart / metabolism*
Mitochondrial Proteins
Models, Biological
Rats
Uncoupling Agents / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Fatty Acids; 0/Ion Channels; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/Uncoupling Agents; 0/mitochondrial uncoupling protein; 0/mitochondrial uncoupling protein 3

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