Document Detail

Fatty acid consumption and metabolic syndrome components: the GOCADAN study.
MedLine Citation:
PMID:  18059206     Owner:  NLM     Status:  MEDLINE    
Fatty acids (FAs) have been related to changes in glucose and lipid metabolism. In this article, the authors assess the association between intake of specific FAs and components of the metabolic syndrome (MS) in adult Eskimos. A total of 691 Inupiat Eskimos (325 men and 366 women), aged 34 to 75 years, were examined as part of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. The investigation included a physical examination, blood pressure measurements, blood sampling under fasting conditions, 2-hour oral glucose tolerance test, and a personal interview including a validated food frequency questionnaire. Components of MS were defined according to the Third Report of the National Cholesterol Education Program Adult Treatment Panel criteria. Consumption of individual FAs showed associations with MS components. Long-chain omega-3 FAs, from fish and sea mammals, were associated with lower blood pressure, serum triglycerides, and 2-hour glucose and higher high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment. Saturated fat consumption was associated with higher triglyceride levels and blood pressure. Trans-FA consumption was associated with higher blood pressure. Consumption of long-chain omega-3 FAs from marine sources may improve certain MS components, and thus may reduce risk for cardiovascular disease. High consumption of saturated FAs and trans-FAs may have an adverse effect on MS.
Sven O E Ebbesson; M Elizabeth Tejero; Elizabeth D Nobmann; Juan Carlos Lopez-Alvarenga; Lars Ebbesson; Terri Romenesko; Elizabeth A Carter; Helaine E Resnick; Richard B Devereux; Jean W MacCluer; Bennett Dyke; Sandra L Laston; Charlotte R Wenger; Richard R Fabsitz; Anthony G Comuzzie; Barbara V Howard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the cardiometabolic syndrome     Volume:  2     ISSN:  1559-4564     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101284690     Medline TA:  J Cardiometab Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
Norton Sound Health Corp, Nome, AK, USA.
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MeSH Terms
Alaska / epidemiology
Blood Glucose / metabolism
Blood Pressure
Fatty Acids, Omega-3 / administration & dosage*,  blood*
Insulin Resistance
Inuits / statistics & numerical data*
Linear Models
Lipids / blood
Metabolic Syndrome X / blood*,  epidemiology,  ethnology*
Middle Aged
Nutrition Surveys
Risk Factors
Statistics, Nonparametric
Waist-Hip Ratio
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Omega-3; 0/Lipids

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