Document Detail

Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children.
MedLine Citation:
PMID:  16441930     Owner:  NLM     Status:  MEDLINE    
There is a relationship between the fatty acid profile in skeletal muscle phospholipids and peripheral resistance to insulin in adults, but similar data have not been reported in infancy and childhood. The objective of this study was to investigate the fatty acid composition of skeletal muscle and adipose tissue across the paediatric age range. The fatty acid profile of skeletal muscle phospholipids and adipose tissue triacylglycerols was analysed in ninety-three healthy Spanish infants and children distributed into four groups: group 1 (0 to <2 years, n 10); group 2 (2 to <5 years, n 41); group 3 (5 to <10 years, n 24); group 4 (10 to 15 years, n 18). In skeletal muscle phospholipids, oleic acid (18: 1n-9cis) content decreased significantly whereas that of linoleic (18: 2n-6) acid increased significantly with age (P for trend <0.01). In adipose tissue, the contents of triacylglycerol and linoleic acid increased significantly across the paediatric age range (P for trend <0.01), whereas dihomo-gamma-linolenic (20: 3n-6) and arachidonic (20: 4n-6) showed significant differences between groups. The variations in fatty acid composition observed with age indicated an imbalance in dietary n-3/n-6 long-chain PUFA.
Pablo Sanjurjo; Luis Aldámiz-Echevarría; Carmen Prado; Isabel Azcona; Javier Elorz; José A Prieto; José I Ruiz; Juan Rodríguez-Soriano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  95     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Division of Metabolism, Hospital de Cruces and Basque University School of Medicine, Bilbao, Spain.
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MeSH Terms
8,11,14-Eicosatrienoic Acid / analysis
Adipose Tissue / chemistry*
Arachidonic Acid / analysis
Child, Preschool
Fatty Acids / analysis*
Muscle, Skeletal / chemistry*
Oleic Acid / analysis
Palmitic Acid / analysis
Phospholipids / analysis
Triglycerides / analysis
alpha-Linolenic Acid / analysis
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 112-80-1/Oleic Acid; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid; 57-10-3/Palmitic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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