Document Detail

Fatty acid composition of serum phospholipid of premenopausal women and postmenopausal women receiving and not receiving hormone replacement therapy.
MedLine Citation:
PMID:  14501607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the fatty acid composition of serum phospholipid of premenopausal women with that of postmenopausal women receiving and not receiving hormone replacement therapy (HRT). DESIGN: Women between the ages of 43 and 70 were recruited for two separate case-comparison studies. Participants were grouped as either premenopausal, postmenopausal receiving HRT, or postmenopausal not receiving HRT. All participants were required to complete a 3-day dietary record before providing a 12-h fasting blood sample. Fatty acid composition of phospholipids and lipid concentrations was determined from serum samples. RESULTS: The postmenopausal women receiving HRT had significantly higher concentrations of palmitic acid (16:0), palmitoleic acid (16:1), and di-homo-gamma-linolenic (20:3n-6) and significantly lower levels of docosapentaenoic acid (22:5n-3) than the other groups in both studies. In addition, the postmenopausal women receiving HRT had lower levels of behenic (22:0), lignoceric (24:0), and nervonic acid (24:1) in comparison with the postmenopausal women not receiving HRT. CONCLUSION: The results of this study indicate that the fatty acid composition of serum phospholipids in women is influenced by menopausal status and hormone use. These results are of interest because high levels of 20:3n-6 and low levels of docosapentaenoic acid have been associated with increased myocardial infarction plus stroke mortality from cardiovascular disease.
Ken D Stark; Eek J Park; Bruce J Holub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  10     ISSN:  1072-3714     ISO Abbreviation:  Menopause     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-09-22     Completed Date:  2003-12-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-55     Citation Subset:  IM    
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
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MeSH Terms
Case-Control Studies
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Contraceptive Agents, Female / pharmacology
Diet Records
Estradiol / pharmacology
Estrogen Replacement Therapy*
Estrogens / pharmacology
Estrogens, Conjugated (USP) / pharmacology
Estrone / analogs & derivatives*,  pharmacology
Fatty Acids / blood*
Medroxyprogesterone Acetate / pharmacology
Middle Aged
Phospholipids / blood*
Progesterone / pharmacology
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Contraceptive Agents, Female; 0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 481-97-0/estrone sulfate; 50-28-2/Estradiol; 53-16-7/Estrone; 57-83-0/Progesterone; 71-58-9/Medroxyprogesterone Acetate

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