| Fatty acid composition of serum phospholipid of premenopausal women and postmenopausal women receiving and not receiving hormone replacement therapy. | |
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MedLine Citation:
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PMID: 14501607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the fatty acid composition of serum phospholipid of premenopausal women with that of postmenopausal women receiving and not receiving hormone replacement therapy (HRT). DESIGN: Women between the ages of 43 and 70 were recruited for two separate case-comparison studies. Participants were grouped as either premenopausal, postmenopausal receiving HRT, or postmenopausal not receiving HRT. All participants were required to complete a 3-day dietary record before providing a 12-h fasting blood sample. Fatty acid composition of phospholipids and lipid concentrations was determined from serum samples. RESULTS: The postmenopausal women receiving HRT had significantly higher concentrations of palmitic acid (16:0), palmitoleic acid (16:1), and di-homo-gamma-linolenic (20:3n-6) and significantly lower levels of docosapentaenoic acid (22:5n-3) than the other groups in both studies. In addition, the postmenopausal women receiving HRT had lower levels of behenic (22:0), lignoceric (24:0), and nervonic acid (24:1) in comparison with the postmenopausal women not receiving HRT. CONCLUSION: The results of this study indicate that the fatty acid composition of serum phospholipids in women is influenced by menopausal status and hormone use. These results are of interest because high levels of 20:3n-6 and low levels of docosapentaenoic acid have been associated with increased myocardial infarction plus stroke mortality from cardiovascular disease. |
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Authors:
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Ken D Stark; Eek J Park; Bruce J Holub |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 10 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2003-09-22 Completed Date: 2003-12-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 448-55 Citation Subset: IM |
Affiliation:
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Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA. kstark@n3pufa.org |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Cholesterol, HDL / blood Cholesterol, LDL / blood Contraceptive Agents, Female / pharmacology Diet Records Estradiol / pharmacology Estrogen Replacement Therapy* Estrogens / pharmacology Estrogens, Conjugated (USP) / pharmacology Estrone / analogs & derivatives*, pharmacology Fatty Acids / blood* Female Humans Medroxyprogesterone Acetate / pharmacology Middle Aged Phospholipids / blood* Postmenopause* Premenopause* Progesterone / pharmacology Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Contraceptive Agents, Female; 0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 481-97-0/estrone sulfate; 50-28-2/Estradiol; 53-16-7/Estrone; 57-83-0/Progesterone; 71-58-9/Medroxyprogesterone Acetate |
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