| Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities. | |
| | |
MedLine Citation:
|
PMID: 21801123 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: To determine whether the fatty acid composition of mid-trimester amniotic fluid differs by ethnicity and pregnancy outcome. Methods: Fatty acid composition was analyzed by gas chromatography in 198 women undergoing amniocentesis at 15-19 weeks gestation. Cytokine levels were determined by ELISA in a subgroup of 52 subjects. Results: The major fatty acids detected were palmitic acid (31.8%) and stearic acid (31.5%). The n-6 polyunsaturated fatty acids (PUFA), linoleic acid (LA, 18:2) and arachidonic acid (AA, 20:4), were 11.3%, while the n-3 PUFA fatty acids, α linolenic acid (ALA, 18:3) and docosahexaenoic acid (DHA, 22:6), were 3.8% of the total. Palmitic acid was a higher percentage in Asians (40.5%) and Whites (34.5%) than in Blacks (22.2%) and Hispanics (23.7%,) (p ≤ 0.0012). Oleic acid (18:1 n-9) was a higher percentage in Blacks (12.2%) and Hispanics (12.1%) than in Whites (9.2%) or Asians (7.5%) (≤0.0002). LA and AA were higher in Blacks (9.0%, 5.4%) and Hispanics (8.6%, 4.1%) than in Whites (6.1%, 3.7%) and Asians (5.5%, 2.9%) (p ≤ 0.0002). DHA did not differ among the ethnic groups or according to pregnancy outcome. A reduced palmitic acid percentage was identified in the six women with preeclampsia (p = 0.0233). Tumor necrosis factor-α levels were inversely proportional to the palmitic acid percentage (p = 0.0275) and positively associated with the percentages of stearic (18:0) (p = 0.0132) and oleic (p = 0.0290) acids. Conclusions: Amniotic fluid fatty acid composition differed among the ethnic groups and may influence inflammatory mediator production and susceptibility to preeclampsia. |
| | |
Authors:
|
Steven S Witkin; Daniel Skupski; Catherine Herway; Marilza V C Rudge; Felipe Saito; Mary Harris |
Related Documents
:
|
8020623 - Defensive use of an acquired substance (carminic acid) by predaceous insect larvae. 7070173 - Amino acid profiles in inner ear fluids and cerebrospinal fluid. 573033 - Amino acid content in relation to growth of helminthosporium maydis nishikado and miyake. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-1 |
Journal Detail:
|
Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University , New York, New York , USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gestational diabetes: comparision of the carpenter and the coustan thresholds with the new threshold...
Next Document: Red clover and soy isoflavones-an in vitro safety assessment.