Document Detail


Fatty acid composition of lymphocytes and macrophages from rats fed fiber-rich diets: a comparison between oat bran- and wheat bran-enriched diets.
MedLine Citation:
PMID:  9208386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of oat bran- (OBD) and wheat bran-enriched diets (WBD) on fatty acid composition of neutral lipids and phospholipids of rat lymphocytes and macrophages was investigated. In neutral lipids of lymphocytes, OBD reduced the proportion of palmitoleic acid (48%), whereas WBD reduced by 43% palmitoleic acid and raised oleic (18%), linoleic (52%), and arachidonic (2.5-fold) acids. In neutral lipids of macrophages, OBD increased palmitic (16%) and linoleic (29%) acids and slightly decreased oleic acid (15%). The effect of WBD, however, was more pronounced: It reduced myristic (60%), stearic (24%) and arachidonic (63%) acids, and it raised palmitic (30%) and linoleic (2.3-fold) acids. Neither OBD nor WBD modified the composition of fatty acids in phospholipids of lymphocytes. In contrast, both diets had a marked effect on composition of fatty acids in macrophage phospholipids. OBD raised the proportion of myristic (42%) and linoleic (2.4-fold) acids and decreased that of lauric (31%), palmitoleic (43%), and arachidonic (29%) acids. WBD increased palmitic (18%) and stearic (23%) acids and lowered palmitoleic (35%) and arachidonic (78%) acids. Of both cells, macrophages were more responsive to the effect of the fiber-rich diets on fatty acid composition of phospholipids. The high turnover of fatty acids in macrophage membranes may explain the differences between both cells. The modifications observed due to the effects of both diets were similar in few cases: an increase in palmitic and linoleic acids of total neutral lipids occurred and a decrease in palmitoleic and arachidonic acids of phospholipid. Therefore, the mechanism involved in the effect of both diets might be different.
Authors:
C R Felippe; P C Calder; M G Vecchia; M R Campos; J Mancini-Filho; E A Newsholme; R Curi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  32     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-27     Completed Date:  1997-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Methodist University of Piracicaba, SP, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avena sativa / chemistry
Diet
Dietary Fiber / pharmacology*
Fatty Acids / analysis*,  blood,  metabolism
Lipids / chemistry
Lymphocytes / chemistry*,  drug effects,  metabolism
Macrophages / chemistry*,  drug effects,  metabolism
Male
Phospholipids / chemistry
Rats
Rats, Wistar
Solubility
Triticum / chemistry
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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