Document Detail

Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia.
MedLine Citation:
PMID:  11597788     Owner:  NLM     Status:  MEDLINE    
The composition of phospholipid fatty acids (PLFA) of separated mononuclear blood cells (MNC) from patients with leukemia was established by high-resolution gas chromatography. Abnormal fatty acid concentrations are detected in the MNC membrane phospholipids in patients with acute lymphoblastic leukemia (ALL) without a deficiency of essential fatty acids (EFA). Significantly reduced relative levels of linoleic acid (4.35 vs. 7.82%; P<0.001) are found in the MNC-PL in patients with ALL as compared to a healthy control group. Moreover, the Delta6-desaturated fatty acids are increased: gamma-linoleic acid (3.56 vs. 0.17%; P<0.001), arachidonic acid (21.82 vs. 16.27%; P<0.05), docosatetraenoic acid (3.52 vs. 1.56%; P<0.001), docosapentaenoic acid (0.34 vs. 0.04%; P<0.001), octadecatetraenoic acid (0.53 vs. 0.23%; P<0.05), eicosatetraenoic acid (1.83 vs. 0.08%; P<0.001) and docosahexaenoic acid (2.77 vs. 1.54%; P<0.001). A increased Delta(6)-desaturase activity is postulated as the cause for the increased level of desaturate products or the increased Delta6-activity index (Ratio of gamma-linoleic acid+dihomogamma-linolenic acid to linoleic acid) (1.21 vs. 0.27; P<0.001). The Delta6-enzyme activities measured using linoleic acid and alpha-linoleic acid as substrate underscore these findings (Delta6(n-6); 2.49 vs. 0.65 and Delta6(n-3); 2.75 vs. 1.12 nmol x h(-1)/10(8) MNC). In contrast, patients with acute myeloid leukemia (AML) do not show any significant differences in the lymphocyte membrane PLFA and no Delta6-desaturase abnormalities.
G Agatha; R Häfer; F Zintl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  173     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Friedrich-Schiller-University of Jena, Children's Hospital, Department of Pediatrics, Endocrinology and Metabolism, Kochstrasse 2, D-07745, Jena, Germany.
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MeSH Terms
Arachidonic Acid / biosynthesis
Cell Membrane / metabolism*
Child, Preschool
Chromatography, Gas
Erucic Acids
Fatty Acids / metabolism*
Fatty Acids, Unsaturated / metabolism
Leukemia, Myeloid, Acute / blood,  metabolism
Lymphocytes / metabolism*
Phospholipids / metabolism*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood,  metabolism*
alpha-Linolenic Acid / metabolism
gamma-Linolenic Acid / biosynthesis
Reg. No./Substance:
0/Erucic Acids; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 463-40-1/alpha-Linolenic Acid; 506-26-3/gamma-Linolenic Acid; 506-32-1/Arachidonic Acid

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