Document Detail


Fatty acid composition of lung, macrophage and surfactant phospholipids after short-term enteral feeding with n-3 lipids.
MedLine Citation:
PMID:  7815899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Utilization of enteral feeding modalities may prove clinically relevant for rapid modulation of lung phospholipid polyunsaturated fatty acids (PUFA) that serve as substrates for the formation of vasoactive dienoic eicosanoids. We compared the effects of short-term enteral feeding with formulations enriched with either fish (n-3) or corn (n-6) oil PUFA on the fatty acid composition of rat lung, alveolar macrophage and surfactant phospholipids. The diets were infused continuously for 72 h through a surgically placed gastroduodenal feeding catheter by a syringe pump. The n-3 PUFA derived from the fish oil enriched diet were readily incorporated into the phospholipid membranes of the alveolar macrophages, lung tissue and pulmonary surfactant. The relative percentages of the n-3 PUFA were significantly higher and individual and total n-6 PUFA significantly lower in the macrophage, lung and surfactant phospholipids from the n-3-supplemented rats in comparison with those present in the rats infused enterally with the n-6 diet or untreated, chow-fed rats (baseline). In contrast, there was a significant increase in linoleic acid (18:2n-6) without modification of arachidonic acid (20:4n-6) in the alveolar macrophages, lung tissue and surfactant from rats enterally receiving the n-6 diet relative to levels measured in the rats at baseline. The results suggest that short-term continuous delivery of n-3-enriched enteral preparations can foster rapid modification of membrane phospholipid PUFA composition of lung tissue, alveolar macrophages and lung surfactant.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J D Palombo; E E Lydon; P L Chen; B R Bistrian; R A Forse
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  29     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-09     Completed Date:  1995-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  643-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215.
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MeSH Terms
Descriptor/Qualifier:
Animals
Corn Oil / administration & dosage
Enteral Nutrition
Fatty Acids / chemistry,  metabolism*
Fatty Acids, Omega-3 / administration & dosage*
Fish Oils / administration & dosage
Humans
Lung / chemistry,  metabolism*
Macrophages, Alveolar / chemistry,  metabolism
Male
Phospholipids / chemistry,  metabolism*
Pulmonary Surfactants / chemistry,  metabolism
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK31933/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 0/Pulmonary Surfactants; 8001-30-7/Corn Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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