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Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality.
MedLine Citation:
PMID:  21466599     Owner:  NLM     Status:  Publisher    
Objectives: Free fatty acids (FFAs) are the major energy sources of the heart and fatty acids (FAs) are active components of biological membranes. Data indicate that levels of FAs and their composition may influence myocardial function and inflammation. The aim of this study was to investigate whether total levels and composition of FAs and FFAs in plasma are altered in clinical heart failure (HF) and whether any alterations in these parameters are correlated with the severity of HF. Subjects: Plasma from 183 patients with stable HF was compared with plasma from 44 healthy control subjects. Results: Our main findings were: (i) patients with HF had decreased levels of several lipid parameters and increased levels of FFAs in plasma, compared to controls, which were significantly correlated with clinical disease severity. (ii) Patients with HF also had a decreased proportion in the plasma of several n-3 polyunsaturated FAs, an increased proportion of several monounsaturated FAs, and a decreased proportion of some readily oxidised long-chain saturated FAs. (iii) These changes in FA composition were significantly associated with functional class, impaired cardiac function (i.e., decreased cardiac index and increased plasma N-terminal pro-B-type natriuretic peptide levels) and enhanced systemic inflammation (i.e., increased high-sensitivity C-reactive protein levels). (iv) Low levels of C20:4n-3 (eicosatetraenoic acid) and in particular high levels of C18:1n-7 (vaccenic acid) were significantly associated with total mortality in this HF population. Conclusions: Our data demonstrate that HF patients are characterised by a certain FA phenotype, and may support a link between disturbed FA composition and the progression of HF.
Erik Oie; Thor Ueland; Christen P Dahl; Pavol Bohov; Christ Berge; Arne Yndestad; Lars Gullestad; Pål Aukrust; Rolf K Berge
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Journal of internal medicine     Volume:  -     ISSN:  1365-2796     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 The Association for the Publication of the Journal of Internal Medicine.
Research Institute for Internal Medicine Department of Cardiology Section of Endocrinology Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway Center for Heart Failure Research Faculty of Medicine, University of Oslo, Oslo, Norway Department of Heart Disease, Haukeland University Hospital Section of Medical Biochemistry, Institute of Medicine, University of Bergen, Bergen, Norway.
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