Document Detail

Fatty acid composition in breast milk and serum phospholipids of healthy term Chinese infants during first 6 weeks of life.
MedLine Citation:
PMID:  17937688     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the fatty acid (FA) pattern in early and mature breast milk with that in plasma phospholipids of cord blood and breast-fed infants. METHODS: Forty-five mother-infant pairs from western Shanghai were studied. All infants, born at term with normal weight and length, were examined at birth and days 5 and 42. FA was analyzed by capillary gas-liquid chromatography. RESULTS: Cord blood showed higher concentration of long-chain polyunsaturated FA (LCPUFA) but lower saturated (SFA) and monounsaturated (MUFA) FA than postnatal infants' plasma. SFA decreased with age in the infants, but MUFA and linoleic acid (LA, 18:2omega6) increased. LCPUFA were lower in the plasma of 5-day-old infants than in cord blood, but LA was 80%, alpha-linolenic acid (ALA, 18:3omega3) 33% and the ratio omega-6/omega-3 42% higher. At day 42, LA increased further, LCPUFA remained similar, and was in breast milk lower than at day 5, while ALA and gamma-linolenic acid (18:3omega6) were higher. The activity index of desaturases indicated high Delta9 activity in breast milk and high activity of Delta5 desaturase in the infants. CONCLUSION: Breast milk FA composition changed markedly from day 5 to 42 with increasing correlation to infants' plasma. Calculation of desaturase activities suggested high capacity of LCPUFA synthesis.
Y M Peng; T Y Zhang; Q Wang; R Zetterström; B Strandvik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-16     Completed Date:  2008-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1640-5     Citation Subset:  IM    
Department of Child Health Care, Children's Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Breast Feeding
Fatty Acids / analysis*,  blood
Fetal Blood / chemistry*
Gas Chromatography-Mass Spectrometry
Infant, Newborn
Maternal Nutritional Physiological Phenomena
Milk, Human / chemistry*
Phospholipids / blood*
Time Factors
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids

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