| Fatty acid composition of hepatic triglycerides in Reye's syndrome: implications for hepatic desaturase abnormalities. | |
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MedLine Citation:
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PMID: 1819459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum NEFA profiles in Reye's syndrome are reportedly unique with a disproportionate percent made up of polyunsaturated fatty acids some of which are not ordinarily found in the serum. This pattern is also reflected in the serum triglyceride composition as well. As the liver is probably the sole source of the serum triglyceride in Rye's syndrome because patients are vomiting or in coma, the fatty acid acid composition of the liver triglyceride was examined for insight regarding the lipid abnormalities in this disease. Palmitic acid (16:0) and the sum of all the saturated fatty acids in the liver triglycerides were significantly decreased whereas the sum of the monoenoic fatty acids and the products of delta 9 desaturase activity were increased in Reye's samples. When these data were compared to the fatty acid composition of the serum triglyceride from a separate cohort of Reye's and control subjects, certain inferences regarding hepatic delta 9, delta 6, delta 5, and delta 4 desaturase activities and the elongases can be drawn from the liver and serum triglyceride fatty acid profiles which are unique. Collectively, these data reflect considerable intrahepatic fatty acid desaturation and elongation activity and/or acyl transfer from lipid to lipid of various polyunsaturated fatty acids in Reye's syndrome. |
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Authors:
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E S Kang; S B Johnson; R T Holman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 204 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 167-77 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Tennessee-Memphis 38163. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Fatty Acid Desaturases / metabolism* Fatty Acids / analysis, blood, metabolism* Fatty Acids, Nonesterified / blood Humans Infant Liver / metabolism* Reference Values Reye Syndrome / blood, enzymology, metabolism* Triglycerides / analysis, blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK-38321/DK/NIDDK NIH HHS; NS-14304/NS/NINDS NIH HHS; P30 AM34931/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Triglycerides; EC 1.14.19.-/Fatty Acid Desaturases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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