| Fatty acid composition of erythrocyte phospholipids is related to insulin levels, secretion and resistance in obese type 2 diabetics on Metformin. | |
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MedLine Citation:
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PMID: 15256315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Relationships between fatty acids in erythrocyte phospholipids and insulin parameters have been described in healthy and overweight individuals, but not in obese diabetics. We assessed whether erythrocyte phospholipid fatty acids are related to insulin parameters in obese type 2 diabetics on Metformin. METHODS: In 23 diabetics, the fractions of the different fatty acids in erythrocyte phospholipids were correlated with insulin levels, secretion, sensitivity, resistance and insulinemic response following a standardised breakfast. RESULTS: Fasting insulin levels and insulin resistance correlated positively with the fraction of alpha-linolenic and dihomo-gamma-linolenic acid and with the ratios of stearic to palmitic and dihomo-gamma-linolenic to linoleic acid and negatively with the fraction of palmitic acid in erythrocyte phospholipids. Insulin secretion correlated negatively with the fraction of palmitic acid. For this parameter, a positive correlation was also found with the sum of uneven fatty acids. Insulinemic response following a meal was negatively associated with the fraction of oleic acid in erythrocyte phospholipids. Insulin sensitivity did not correlate with erythrocyte fatty acids. CONCLUSIONS: The relationships found differ from those described in healthy and overweight individuals and may be characteristic for type 2 diabetics. They concur with the recommendations that saturated fat intake should be reduced and monounsaturated increased. |
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Authors:
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Yanik Rodríguez Enriquez; Mimi Giri; Raoul Rottiers; Armand Christophe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 346 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-16 Completed Date: 2005-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biochemistry, Institute of Nutrition and Food Hygiene, Havana, Cuba. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Biological Markers / blood Diabetes Mellitus, Type 2 / blood* Dietary Fats / pharmacology Erythrocytes / chemistry* Fatty Acids / blood* Humans Insulin / blood*, metabolism Insulin Resistance / physiology Male Metformin / therapeutic use Middle Aged Obesity / blood* Phospholipids / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Fatty Acids; 0/Phospholipids; 11061-68-0/Insulin; 657-24-9/Metformin |
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