Document Detail

Fatty acid composition of epicardial and subcutaneous human adipose tissue.
MedLine Citation:
PMID:  19422139     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epicardial adipose tissue has special properties that distinguish it from the more widely studied depots of adipose tissue. OBJECTIVES: We undertook this study to investigate regional differences between epicardial and subcutaneous adipose tissue fat composition, as well as associations between these measures and metabolic variables. METHODS: Epicardial and subcutaneous peripheral adipose tissue were collected during coronary artery bypass grafting from 42 patients (ages 37-65) with coronary artery disease (CAD). The fatty acid composition of adipose tissue was determined by gas liquid chromatography (GLC). RESULTS: The saturated fatty acids, including myristic acid (14:0), palmitic acid (16:0), and stearic acid (18:0), were higher, and the unsaturated fatty acids, including palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6), and linolenic acid (18:3n-3), were lower than the subcutaneous adipose tissue. The presence of hypertension was positively correlated with the 16:1n-7 (r = 0.407, P = 0.032) and 18:1n-11(r = 0.370, P = 0.027), and negatively correlated with 18:1n-9 (r = -0.367, P = 0.036) and 18:2n-6 (r = -0.446, P = 0.006) contents of epicardial adipose tissue after adjustment for body mass index. CONCLUSIONS: Regional differences may be observed in fatty acid composition, suggesting a depot specific impact of stored fatty acids on adipocyte function and metabolism.
Masoud Pezeshkian; Mohammad Noori; Hamideh Najjarpour-Jabbari; Aliakbar Abolfathi; Maryam Darabi; Masoud Darabi; Maghsod Shaaker; Ghader Shahmohammadi
Related Documents :
15932099 - Characterization of adipocere formation in animal species.
11108729 - Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women.
7942579 - Human subcutaneous adipose tissue shows site-specific differences in fatty acid composi...
21910059 - Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway a...
8077579 - Type a behavior and adipose tissue linoleic acid: implications for stress management.
2866129 - Bidirectional transfer and tissue accumulation of folic acid by rat intestine in vitro.
17952609 - Acidogenic fermentation of proteinaceous solid waste and characterization of different ...
10727879 - Improvement of intestinal peptide absorption by a synthetic bile acid derivative, choly...
17979289 - Convergent and stereospecific synthesis of molecules containing alpha-functionalized gu...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  7     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-07-16     Revised Date:  2010-11-03    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Cardiovascular Research Center and 2Department of Biochemistry, School of Medicine, Tabriz University, Medical Sciences, Tabriz, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue, White / chemistry*
Coronary Artery Bypass
Coronary Artery Disease / metabolism,  surgery
Fatty Acids / analysis*
Fatty Acids, Unsaturated / analysis*
Hypertension / metabolism
Middle Aged
Pericardium / chemistry*
Subcutaneous Fat / chemistry*
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Doing their part for reform. Many of the Top 25 Women in Healthcare are on the front lines of reform...
Next Document:  Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.