| Fatty acid composition of epicardial and subcutaneous human adipose tissue. | |
MedLine Citation:
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PMID: 19422139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epicardial adipose tissue has special properties that distinguish it from the more widely studied depots of adipose tissue. OBJECTIVES: We undertook this study to investigate regional differences between epicardial and subcutaneous adipose tissue fat composition, as well as associations between these measures and metabolic variables. METHODS: Epicardial and subcutaneous peripheral adipose tissue were collected during coronary artery bypass grafting from 42 patients (ages 37-65) with coronary artery disease (CAD). The fatty acid composition of adipose tissue was determined by gas liquid chromatography (GLC). RESULTS: The saturated fatty acids, including myristic acid (14:0), palmitic acid (16:0), and stearic acid (18:0), were higher, and the unsaturated fatty acids, including palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6), and linolenic acid (18:3n-3), were lower than the subcutaneous adipose tissue. The presence of hypertension was positively correlated with the 16:1n-7 (r = 0.407, P = 0.032) and 18:1n-11(r = 0.370, P = 0.027), and negatively correlated with 18:1n-9 (r = -0.367, P = 0.036) and 18:2n-6 (r = -0.446, P = 0.006) contents of epicardial adipose tissue after adjustment for body mass index. CONCLUSIONS: Regional differences may be observed in fatty acid composition, suggesting a depot specific impact of stored fatty acids on adipocyte function and metabolism. |
Authors:
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Masoud Pezeshkian; Mohammad Noori; Hamideh Najjarpour-Jabbari; Aliakbar Abolfathi; Maryam Darabi; Masoud Darabi; Maghsod Shaaker; Ghader Shahmohammadi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: 7 ISSN: 1557-8518 ISO Abbreviation: Metab Syndr Relat Disord Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-06 Completed Date: 2009-07-16 Revised Date: 2010-11-03 |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: United States |
Other Details:
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Languages: eng Pagination: 125-31 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Center and 2Department of Biochemistry, School of Medicine, Tabriz University, Medical Sciences, Tabriz, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, White
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chemistry* Adult Aged Coronary Artery Bypass Coronary Artery Disease / metabolism, surgery Fatty Acids / analysis* Fatty Acids, Unsaturated / analysis* Female Humans Hypertension / metabolism Male Middle Aged Pericardium / chemistry* Subcutaneous Fat / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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