| Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance. The Diogenes Study. | |
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MedLine Citation:
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PMID: 23098653 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. To assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8% weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycaemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors. |
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Authors:
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M Kunešová; P Hlavatý; E Tvrzická; B Staňková; P Kalousková; N Viguerie; T M Larsen; M A Van Baak; S A Jebb; J A Martinez; A Fh Pfeiffer; A Kafatos; T Handjieva-Darlenska; M Hill; D Langin; A Zák; A Astrup; W Hm Saris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-25 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: - ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Endocrinology, Prague, Czech Republic. mkunesova@endo.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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