Document Detail


Fatty acid chain length and degree of unsaturation are inversely associated with serum triglycerides.
MedLine Citation:
PMID:  11132178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the association between dietary fatty acids and serum triglycericle concentrations. Plasma fatty acids may reflect dietary intake and can be used to study the relationship between concentrations of individual fatty acids and serum lipids. We examined the cross-sectional relationship of plasma fatty acids with serum nonfasting triglyceride and total cholesterol concentrations. Relative concentrations of individual plasma phospholipid fatty acids were determined by gas liquid chromatography among 4,158 men aged 40-42 yr, who participated in a population study. The pattern of associations between individual fatty acids and cholesterol was different from that between individual fatty acids and triglyceride concentrations. All fatty acids displayed positive associations with total cholesterol concentration except linoleic acid, which was inversely related to cholesterol. In contrast, associations between individual fatty acids and triglyceride concentrations differed in strength and direction depending on both carbon chain length and the degree of unsaturation. Concentrations of very long chain (20 carbon atoms or more) saturated, monounsaturated, and n-3 polyunsaturated fatty acids showed significant inverse associations with triglycerides, whereas shorter fatty acids within these classes were positively associated with triglyceride concentrations. The present data suggest that the associations between concentrations of serum triglycerides and plasma phospholipid fatty acids depend on both fatty acid chain length and the degree of unsaturation.
Authors:
S Grimsgaard; K H Bønaa; K S Bjerve
Related Documents :
688608 - Spectrodensitometry of nanogram quantities of cholesterol.
1793508 - Hypolipidemic activity of aliphatic dicarboxylic acids in rodents.
1643098 - Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in ...
22070338 - Theory of the short time mechanical relaxation in articular cartilage.
1992628 - The effect of fasting on 24-hour intragastric acidity and plasma gastrin concentration.
606558 - Organic aciduria in hypoxic premature newborns simulating an inborn error of metabolism.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  35     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-22     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1185-93     Citation Subset:  IM    
Affiliation:
lnstitute of Community Medicine, University of Trømso, Norway. sameline@farmasi.uit.no
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Cholesterol / blood
Chromatography, Gas
Cross-Sectional Studies
Diet
Fatty Acids / blood,  chemistry*
Female
Fish Products
Humans
Life Style
Male
Phospholipids / blood
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovasc...
Next Document:  Discovery of an 11 (R)- and 12(S)-lipoxygenase activity in ovaries of the mussel Mytilus edulis.