Document Detail

Fatty acid-based polyurethane films for wound dressing applications.
MedLine Citation:
PMID:  18839285     Owner:  NLM     Status:  MEDLINE    
Fatty acid-based polyurethane films were prepared for use as potential wound dressing material. The polymerization reaction was carried out with or without catalyst. Polymer films were prepared by casting-evaporation technique with or without crosslink-catalyst. The film prepared from uncatalyzed reaction product with crosslink-catalyst gave slightly higher crosslink density. The mechanical tests showed that, the increase in the tensile strength and decrease in the elongation at break is due to the increase in the degree of crosslinking. All films were flexible, and resisted to acid solution. The films prepared without crosslink-catalyst were more hydrophilic, absorbed more water. The highest permeability values were generally obtained for the films prepared without crosslink catalyst. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films and the polyurethane film prepared from uncatalyzed reaction product without crosslink-catalyst showed better biocompatibility property, closest to the commercial product, Opsite.
Guncem Gultekin; Cigdem Atalay-Oral; Sibel Erkal; Fikret Sahin; Djursun Karastova; S Birgul Tantekin-Ersolmaz; F Seniha Guner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-07
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  20     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-31     Citation Subset:  IM    
Delft University of Technology, Delft Chem Tech, 2600 GA, Delft, The Netherland.
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MeSH Terms
Biocompatible Materials / chemical synthesis,  chemistry*,  toxicity
Cell Proliferation / drug effects
Coated Materials, Biocompatible / chemistry
Cross-Linking Reagents
Fatty Acids / chemistry*
Magnetic Resonance Spectroscopy
Materials Testing
Molecular Structure
Molecular Weight
NIH 3T3 Cells
Polyurethanes / chemical synthesis,  chemistry*,  toxicity
Spectroscopy, Fourier Transform Infrared
Surface Properties
Tensile Strength
Reg. No./Substance:
0/Biocompatible Materials; 0/Coated Materials, Biocompatible; 0/Cross-Linking Reagents; 0/Fatty Acids; 0/Polyurethanes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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