Document Detail

Fatty acid alterations and carboxylase deficiencies in the skin of biotin-deficient rats.
MedLine Citation:
PMID:  2333844     Owner:  NLM     Status:  MEDLINE    
Full-thickness biopsies of haired and alopecic skin of biotin-deficient rats had less subcutaneous fat and showed lipophilic follicular plugging, vascular engorgement, epidermal hyperplasia, and abnormal keratinization. Mean activities of the three mitochondrial biotin-dependent carboxylases in the skin of biotin-deficient animals were reduced to 3-18% of control whereas the cytosolic enzyme, acetyl-CoA carboxylase, was reduced only to 38-61%. The total fatty acid content of haired and alopecic skin of deficient rats was 30% of those in the corresponding skin sites of control animals. Skin from deficient rats contained less of several long-chain fatty acids (16:0, 16:1, 18:0, 18:1, and 18:2) and more very-long-chain fatty acid, particularly 24:1 and 26:1. These alterations in fatty acids in biotin-deficient rats suggest that the skin findings in biotin and biotinidase deficiencies in humans may be due to similar fatty acid changes.
V K Proud; W B Rizzo; J W Patterson; G S Heard; B Wolf
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  51     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-07     Completed Date:  1990-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-8     Citation Subset:  AIM; IM    
Department of Human Genetics, Medical College of Virginia, Richmond 23298-0033.
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MeSH Terms
Biotin / administration & dosage,  deficiency*
Carboxylic Ester Hydrolases / metabolism*
Fatty Acids / metabolism*
Rats, Inbred Strains
Skin / enzymology,  metabolism*,  pathology
Grant Support
Reg. No./Substance:
0/Fatty Acids; 58-85-5/Biotin; EC 3.1.1.-/Carboxylic Ester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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